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Aberrant brain functional connectome in patients with obstructive sleep apnea

Overview of attention for article published in Neuropsychiatric Disease and Treatment, April 2018
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Title
Aberrant brain functional connectome in patients with obstructive sleep apnea
Published in
Neuropsychiatric Disease and Treatment, April 2018
DOI 10.2147/ndt.s161085
Pubmed ID
Authors

Li-Ting Chen, XiaoLe Fan, Hai-Jun Li, Cheng-Long Ye, Hong-Hui Yu, HuiZhen Xin, HongHan Gong, De-Chang Peng, LiPing Yan

Abstract

Obstructive sleep apnea (OSA) is accompanied by widespread abnormal spontaneous regional activity related to cognitive deficits. However, little is known about the topological properties of the functional brain connectome of patients with OSA. This study aimed to use the graph theory approaches to investigate the topological properties and functional connectivity (FC) of the functional connectome in patients with OSA, based on resting-state functional magnetic resonance imaging (rs-fMRI). Forty-five male patients with newly diagnosed untreated severe OSA and 45 male good sleepers (GSs) underwent a polysomnography (PSG), clinical evaluations, and rs-fMRI scans. The automated anatomical labeling (AAL) atlas was used to construct the functional brain connectome. The topological organization and FC of brain functional networks in patients with OSA were characterized using graph theory methods and investigated the relationship between functional network topology and clinical variables. Both the patients with OSA and the GSs exhibited high-efficiency "small-world" network attributes. However, the patients with OSA exhibited decreased σ, γ, Eglob; increased Lp, λ; and abnormal nodal centralities in several default-mode network (DMN), salience network (SN), and central executive network (CEN) regions. However, the patients with OSA exhibited abnormal functional connections between the DMN, SN, and CEN. The disrupted FC was significantly positive correlations with the global network metrics γ and σ. The global network metrics were significantly correlated with the Epworth Sleepiness Scale (ESS) score, Montreal Cognitive Assessment (MoCA) score, and oxygen desaturation index. The findings suggest that the functional connectome of patients with OSA exhibited disrupted functional integration and segregation, and functional disconnections of the DMN, SN, and CEN. The aberrant topological attributes may be associated with disrupted FC and cognitive functions. These topological abnormalities and disconnections might be potential biomarkers of cognitive impairments in patients with OSA.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 21%
Researcher 3 16%
Student > Doctoral Student 2 11%
Student > Bachelor 2 11%
Student > Ph. D. Student 1 5%
Other 0 0%
Unknown 7 37%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 11%
Biochemistry, Genetics and Molecular Biology 2 11%
Neuroscience 2 11%
Environmental Science 1 5%
Social Sciences 1 5%
Other 2 11%
Unknown 9 47%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2018.
All research outputs
#12,840,613
of 14,535,828 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,984
of 2,442 outputs
Outputs of similar age
#240,100
of 277,320 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#64
of 77 outputs
Altmetric has tracked 14,535,828 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,442 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,320 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.