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Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects

Overview of attention for article published in Neuropsychiatric Disease and Treatment, March 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

twitter
8 tweeters

Citations

dimensions_citation
16 Dimensions

Readers on

mendeley
30 Mendeley
Title
Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects
Published in
Neuropsychiatric Disease and Treatment, March 2015
DOI 10.2147/ndt.s74898
Pubmed ID
Authors

Giulio Pasinetti, Wei Zhao, Jun Wang, Merina Varghese, Lap Ho, Paolo Mazzola, Vahram Haroutunian, Pavel Katsel, Gary Gibson, Samara Levine, Lauren Dubner

Abstract

Recent evidence shows that Alzheimer disease (AD) dementia in the oldest-old subjects was associated with significantly less amyloid plaque and fibrillary tangle neuropathology than in the young-old population. In this study, using quantitative (q) PCR studies, we validated genome-wide microarray RNA studies previously conducted by our research group. We found selective downregulation of mitochondrial energy metabolism genes in the brains of oldest-old, but not young-old, AD dementia cases, despite a significant lack of classic AD neuropathology features. We report a significant decrease of genes associated with mitochondrial pyruvate metabolism, the tricarboxylic acid cycle (TCA), and glycolytic pathways. Moreover, significantly higher levels of nitrotyrosylated (3-NT)-proteins and 4-hydroxy-2-nonenal (HNE) adducts, which are indexes of cellular protein oxidation and lipid peroxidation, respectively, were detected in the brains of oldest-old subjects at high risk of developing AD, possibly suggesting compensatory mechanisms. These findings support the hypothesis that although oldest-old AD subjects, characterized by significantly lower AD neuropathology than young-old AD subjects, have brain mitochondrial metabolism impairment, which we hypothesize may selectively contribute to the development of dementia. Outcomes from this study provide novel insights into the molecular mechanisms underlying clinical dementia in young-old and oldest-old AD subjects and provide novel strategies for AD prevention and treatment in oldest-old dementia cases.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Netherlands 1 3%
India 1 3%
Unknown 27 90%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 17%
Student > Postgraduate 4 13%
Student > Ph. D. Student 4 13%
Student > Doctoral Student 3 10%
Professor 3 10%
Other 6 20%
Unknown 5 17%
Readers by discipline Count As %
Medicine and Dentistry 8 27%
Agricultural and Biological Sciences 5 17%
Nursing and Health Professions 2 7%
Psychology 2 7%
Engineering 2 7%
Other 5 17%
Unknown 6 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2018.
All research outputs
#7,456,429
of 22,796,179 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,028
of 2,984 outputs
Outputs of similar age
#87,347
of 256,542 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#27
of 67 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,984 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,542 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.