| Title |
Sex differences in TGFB-β signaling with respect to age of onset and cognitive functioning in schizophrenia
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, March 2015
|
| DOI | 10.2147/ndt.s74672 |
| Pubmed ID | |
| Authors |
Lidia Karabon, Dorota Frydecka, Edyta Pawlak-Adamska, Anna Tomkiewicz, Paweł Sedlaczek, Andrzej Kiejna, Jan Aleksander Beszłej, Błażej Misiak |
| Abstract |
There are studies showing that gene polymorphisms within the transforming growth factor-β (TGF-β) signaling constitute schizophrenia risk variants. However, the association between TGFB1 gene polymorphisms (+869T/C and +915G/C), TGF-β level with schizophrenia course, and its symptomatology together with cognitive functioning has not been investigated so far. We included 151 patients with schizophrenia and 279 healthy controls. Cognitive functioning was assessed using Rey Auditory Verbal Learning Test, Trail Making Test (TMT)-A and TMT-B, Verbal Fluency task, Stroop test, as well as selected subtests from the Wechsler Adults Intelligence Scale - Revised, Polish adaptation (WAIS-R-Pl): Digit Symbol Coding, Digit Span Forward and Backward, and Similarities. Additionally, serum TGF-β levels were measured in 88 schizophrenia patients and 88 healthy controls. Serum TGF-β level was significantly higher among patients with schizophrenia in comparison with healthy controls; however, the studied polymorphisms were not associated with TGF-β level in schizophrenia patients. Subjects carrying the +869T allele performed significantly worse in comparison with +869CC homozygotes on Stroop task, Verbal Fluency task and Digit Symbol Coding task. There was a significant difference in age of psychosis onset in female schizophrenia patients with respect to the TGFB1 +869T/C polymorphism. Additionally, adjustment for possible confounders revealed that there was a significant difference in cognitive performance on Digit Symbol Coding task with respect to the TGFB1 +869T/C polymorphism among female schizophrenia patients. Our results suggest that TGF-β signaling might be a valid link contributing to observed differences in age of onset and the level of cognitive decline between male and female schizophrenia patients. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 2% |
| Unknown | 62 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Researcher | 12 | 19% |
| Student > Master | 10 | 16% |
| Student > Doctoral Student | 4 | 6% |
| Other | 4 | 6% |
| Other | 9 | 14% |
| Unknown | 12 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 9 | 14% |
| Medicine and Dentistry | 8 | 13% |
| Neuroscience | 7 | 11% |
| Agricultural and Biological Sciences | 6 | 10% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Other | 8 | 13% |
| Unknown | 20 | 32% |
Attention Score in Context
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