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Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

Overview of attention for article published in Clinical Interventions in Aging, March 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#20 of 1,697)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
8 news outlets
blogs
4 blogs
twitter
5 tweeters
patent
2 patents
facebook
3 Facebook pages
googleplus
1 Google+ user
video
1 video uploader

Citations

dimensions_citation
135 Dimensions

Readers on

mendeley
386 Mendeley
Title
Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment
Published in
Clinical Interventions in Aging, March 2015
DOI 10.2147/cia.s74042
Pubmed ID
Authors

Xiaohua Li, Sean Leng, Dalin Song

Abstract

The aim of this paper is to provide a comprehensive review of the epidemiological evidence linking type 2 diabetes mellitus and its related conditions, including obesity, hyperinsulinemia, and metabolic syndrome, to Alzheimer's disease (AD). Several mechanisms could help to explain this proposed link; however, our focus is on insulin resistance and deficiency. Studies have shown that insulin resistance and deficiency can interact with amyloid-β protein and tau protein phosphorylation, each leading to the onset and development of AD. Based on those epidemiological data and basic research, it was recently proposed that AD can be considered as "type 3 diabetes". Special attention has been paid to determining whether antidiabetic agents might be effective in treating AD. There has been much research both experimental and clinical on this topic. We mainly discuss the clinical trials on insulin, metformin, thiazolidinediones, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase-4 inhibitors in the treatment of AD. Although the results of these trials seem to be contradictory, this approach is also full of promise. It is worth mentioning that the therapeutic effects of these drugs are influenced by the apolipoprotein E (APOE)-ε4 genotype. Patients without the APOE-ε4 allele showed better treatment effects than those with this allele.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 386 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Macao 1 <1%
United Kingdom 1 <1%
Denmark 1 <1%
Unknown 380 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 70 18%
Student > Ph. D. Student 64 17%
Student > Bachelor 61 16%
Researcher 37 10%
Student > Doctoral Student 18 5%
Other 55 14%
Unknown 81 21%
Readers by discipline Count As %
Medicine and Dentistry 75 19%
Neuroscience 47 12%
Agricultural and Biological Sciences 45 12%
Biochemistry, Genetics and Molecular Biology 41 11%
Pharmacology, Toxicology and Pharmaceutical Science 26 7%
Other 52 13%
Unknown 100 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 100. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2021.
All research outputs
#282,629
of 19,503,523 outputs
Outputs from Clinical Interventions in Aging
#20
of 1,697 outputs
Outputs of similar age
#4,172
of 235,186 outputs
Outputs of similar age from Clinical Interventions in Aging
#1
of 16 outputs
Altmetric has tracked 19,503,523 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,697 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,186 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.