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Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control

Overview of attention for article published in International Journal of Nanomedicine, March 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
57 Dimensions

Readers on

mendeley
89 Mendeley
Title
Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control
Published in
International Journal of Nanomedicine, March 2015
DOI 10.2147/ijn.s72923
Pubmed ID
Authors

Naveen Kumar Navani, Paramesh Ramulu Lambadi, Tarun Kumar Sharma, Piyush Kumar, Priyanka Vasnani, Sitaramanjaneya Mouli Thalluri, Neha Bisht, Ranjana Pathania

Abstract

Infectious diseases cause a huge burden on healthcare systems worldwide. Pathogenic bacteria establish infection by developing antibiotic resistance and modulating the host's immune system, whereas opportunistic pathogens like Pseudomonas aeruginosa adapt to adverse conditions owing to their ability to form biofilms. In the present study, silver nanoparticles were biofunctionalized with polymyxin B, an antibacterial peptide using a facile method. The biofunctionalized nanoparticles (polymyxin B-capped silver nanoparticles, PBSNPs) were assessed for antibacterial activity against multiple drug-resistant clinical strain Vibrio fluvialis and nosocomial pathogen P. aeruginosa. The results of antibacterial assay revealed that PBSNPs had an approximately 3-fold higher effect than the citrate-capped nanoparticles (CSNPs). Morphological damage to the cell membrane was followed by scanning electron microscopy, testifying PBSNPs to be more potent in controlling the bacterial growth as compared with CSNPs. The bactericidal effect of PBSNPs was further confirmed by Live/Dead staining assays. Apart from the antibacterial activity, the biofunctionalized nanoparticles were found to resist biofilm formation. Electroplating of PBSNPs onto stainless steel surgical blades retained the antibacterial activity against P. aeruginosa. Further, the affinity of polymyxin for endotoxin was exploited for its removal using PBSNPs. It was found that the prepared nanoparticles removed 97% of the endotoxin from the solution. Such multifarious uses of metal nanoparticles are an attractive means of enhancing the potency of antimicrobial agents to control infections.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 1%
France 1 1%
Unknown 87 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 21%
Researcher 14 16%
Student > Ph. D. Student 14 16%
Student > Bachelor 10 11%
Student > Postgraduate 4 4%
Other 14 16%
Unknown 14 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 18%
Biochemistry, Genetics and Molecular Biology 12 13%
Chemistry 10 11%
Immunology and Microbiology 7 8%
Medicine and Dentistry 6 7%
Other 20 22%
Unknown 18 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2019.
All research outputs
#8,815,745
of 15,380,847 outputs
Outputs from International Journal of Nanomedicine
#1,021
of 2,937 outputs
Outputs of similar age
#103,000
of 226,338 outputs
Outputs of similar age from International Journal of Nanomedicine
#3
of 14 outputs
Altmetric has tracked 15,380,847 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,937 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,338 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.