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Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control

Overview of attention for article published in International Journal of Nanomedicine, March 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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4 X users
patent
1 patent

Citations

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74 Dimensions

Readers on

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105 Mendeley
Title
Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control
Published in
International Journal of Nanomedicine, March 2015
DOI 10.2147/ijn.s72923
Pubmed ID
Authors

Paramesh Ramulu Lambadi, Tarun Kumar Sharma, Piyush Kumar, Priyanka Vasnani, Sitaramanjaneya Mouli Thalluri, Neha Bisht, Ranjana Pathania, Naveen Kumar Navani

Abstract

Infectious diseases cause a huge burden on healthcare systems worldwide. Pathogenic bacteria establish infection by developing antibiotic resistance and modulating the host's immune system, whereas opportunistic pathogens like Pseudomonas aeruginosa adapt to adverse conditions owing to their ability to form biofilms. In the present study, silver nanoparticles were biofunctionalized with polymyxin B, an antibacterial peptide using a facile method. The biofunctionalized nanoparticles (polymyxin B-capped silver nanoparticles, PBSNPs) were assessed for antibacterial activity against multiple drug-resistant clinical strain Vibrio fluvialis and nosocomial pathogen P. aeruginosa. The results of antibacterial assay revealed that PBSNPs had an approximately 3-fold higher effect than the citrate-capped nanoparticles (CSNPs). Morphological damage to the cell membrane was followed by scanning electron microscopy, testifying PBSNPs to be more potent in controlling the bacterial growth as compared with CSNPs. The bactericidal effect of PBSNPs was further confirmed by Live/Dead staining assays. Apart from the antibacterial activity, the biofunctionalized nanoparticles were found to resist biofilm formation. Electroplating of PBSNPs onto stainless steel surgical blades retained the antibacterial activity against P. aeruginosa. Further, the affinity of polymyxin for endotoxin was exploited for its removal using PBSNPs. It was found that the prepared nanoparticles removed 97% of the endotoxin from the solution. Such multifarious uses of metal nanoparticles are an attractive means of enhancing the potency of antimicrobial agents to control infections.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 <1%
France 1 <1%
Unknown 103 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 19%
Researcher 16 15%
Student > Ph. D. Student 15 14%
Student > Bachelor 10 10%
Student > Doctoral Student 4 4%
Other 16 15%
Unknown 24 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 16%
Biochemistry, Genetics and Molecular Biology 14 13%
Chemistry 11 10%
Immunology and Microbiology 8 8%
Pharmacology, Toxicology and Pharmaceutical Science 7 7%
Other 19 18%
Unknown 29 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2023.
All research outputs
#6,373,631
of 25,373,627 outputs
Outputs from International Journal of Nanomedicine
#645
of 4,123 outputs
Outputs of similar age
#66,891
of 270,992 outputs
Outputs of similar age from International Journal of Nanomedicine
#21
of 77 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,992 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.