↓ Skip to main content

Dove Medical Press

Article Metrics

Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells

Overview of attention for article published in Drug Design, Development and Therapy, March 2015
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
36 Mendeley
Title
Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
Published in
Drug Design, Development and Therapy, March 2015
DOI 10.2147/dddt.s77341
Pubmed ID
Authors

Ammad Farooqi, Xiukun Lin, Muhammad Ismail

Abstract

It is becoming increasingly understood that tumor cells may have different mutations and dependencies on diverse intracellular signaling cascades for survival or metastatic potential. Overexpression of oncogenes, inactivation of tumor suppressor genes, genetic/epigenetic mutations, genomic instability, and loss of apoptotic cell death are some of the mechanisms that have been widely investigated in molecular oncology. We partition this multicomponent review into the most recent evidence on the anticancer activity of fungal substances obtained from in vitro and xenografted models, and these fungal substances modulate expression of oncogenic and tumor suppressor miRNAs. There are some outstanding questions regarding fungus-derived chemical-induced modulation of intracellular signaling networks in different cancer cell lines and preclinical models. Certain hints have emerged, emphasizing mechanisms via which apoptosis can be restored in TRAIL-resistant cancer cells. Reconceptualization of the knowledge obtained from these emerging areas of research will enable us to potentially identify natural agents with notable anticancer activity and minimal off-target effects. Integration of experimentally verified evidence obtained from cancer cell line gene expression with large-scale functional screening results and pharmacological sensitivity data will be helpful in identification of therapeutics with substantial efficacy. New tools and technologies will further deepen our understanding of the signaling networks that underlie the development of cancer, metastasis, and resistance to different therapeutics at both a personal and systems-wide level.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
Denmark 1 3%
France 1 3%
Unknown 33 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 19%
Student > Ph. D. Student 6 17%
Student > Bachelor 6 17%
Student > Master 5 14%
Other 4 11%
Other 3 8%
Unknown 5 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 28%
Medicine and Dentistry 9 25%
Biochemistry, Genetics and Molecular Biology 4 11%
Environmental Science 2 6%
Nursing and Health Professions 1 3%
Other 5 14%
Unknown 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2015.
All research outputs
#2,418,409
of 4,977,872 outputs
Outputs from Drug Design, Development and Therapy
#211
of 728 outputs
Outputs of similar age
#78,346
of 150,243 outputs
Outputs of similar age from Drug Design, Development and Therapy
#4
of 15 outputs
Altmetric has tracked 4,977,872 research outputs across all sources so far. This one has received more attention than most of these and is in the 50th percentile.
So far Altmetric has tracked 728 research outputs from this source. They receive a mean Attention Score of 2.1. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 150,243 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.