Title |
Breast cancer therapy and cardiovascular risk: focus on trastuzumab
|
---|---|
Published in |
Vascular Health and Risk Management, April 2015
|
DOI | 10.2147/vhrm.s69641 |
Pubmed ID | |
Authors |
Aamer Sandoo, George D Kitas, Amtul R Carmichael |
Abstract |
Breast cancer is the most common cancer in the UK. Advances in the methods of early diagnosis as well as newer and more effective treatments have led to improvements of disease-free and overall survival over the last decade. Almost one-third of breast cancers present with an aggressive form characterized by increased expression of human epidermal growth receptor 2 (HER2) proteins. A targeted treatment using monoclonal antibodies against HER2 expression such as trastuzumab has been shown to improve survival. Unfortunately, there is a degree of cardiotoxicity associated with these agents, as inhibition of HER2 pathways can also impair cardioprotective pathways. In the present review, we discuss the mechanisms by which trastuzumab might affect vascular homeostasis leading to endothelial dysfunction. We also provide suggestions for future research examining the effects of trastuzumab on the vasculature in breast cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Spain | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 1% |
Ecuador | 1 | 1% |
Unknown | 77 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 14% |
Student > Master | 11 | 14% |
Student > Bachelor | 11 | 14% |
Student > Postgraduate | 6 | 8% |
Student > Ph. D. Student | 5 | 6% |
Other | 13 | 16% |
Unknown | 22 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 26 | 33% |
Agricultural and Biological Sciences | 8 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Nursing and Health Professions | 6 | 8% |
Social Sciences | 3 | 4% |
Other | 7 | 9% |
Unknown | 23 | 29% |