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Reduction-responsive cross-linked stearyl peptide for effective delivery of plasmid DNA

Overview of attention for article published in International Journal of Nanomedicine, May 2015
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Mentioned by

twitter
3 tweeters

Citations

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12 Dimensions

Readers on

mendeley
6 Mendeley
Title
Reduction-responsive cross-linked stearyl peptide for effective delivery of plasmid DNA
Published in
International Journal of Nanomedicine, May 2015
DOI 10.2147/ijn.s82413
Pubmed ID
Authors

Shen Gao, Chong Yao, Zongguang Tai, Xiaoyu Wang, Jiyong Liu, Quangang Zhu, Xin Wu, Lijuan Zhang, Wei Zhang, Jing Tian, Yuan Gao

Abstract

Low efficiency and significant toxicity are the main obstacles to successful gene delivery. We have developed a cationic reduction-responsive vector based on a disulfide cross-linked stearylated polyarginine peptide modified with histidine (C-SHR) for DNA delivery. The structure of the C-SHR was characterized, and the in vitro and in vivo transfection efficiency and cytotoxicity of C-SHR/plasmid DNA complexes were examined. Compared with non-cross-linked stearylated polyarginine peptide (SHR), C-SHR increased the intracellular uptake and dissociation behavior of the complexes. In addition, the gene transfection efficiency of C-SHR/plasmid DNA complexes in HEK293 and HeLa cells was improved and was comparable with that of bPEI-25K/plasmid DNA complexes, and the cytotoxicity of C-SHR was significantly less than that of bPEI-25K. Importantly, the in vivo gene transfection efficiency of C-SHR/plasmid DNA complexes was five fold higher than that of SHR/plasmid DNA complexes, suggesting that C-SHR is an efficient non-viral vector for DNA delivery.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 17%
Researcher 1 17%
Unknown 4 67%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 1 17%
Unknown 5 83%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2015.
All research outputs
#2,509,966
of 5,085,280 outputs
Outputs from International Journal of Nanomedicine
#468
of 1,341 outputs
Outputs of similar age
#84,891
of 161,169 outputs
Outputs of similar age from International Journal of Nanomedicine
#24
of 53 outputs
Altmetric has tracked 5,085,280 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,341 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,169 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.