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Effects of PVA coated nanoparticles on human immune cells

Overview of attention for article published in International Journal of Nanomedicine, May 2015
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Mentioned by

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3 tweeters

Citations

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21 Dimensions

Readers on

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33 Mendeley
Title
Effects of PVA coated nanoparticles on human immune cells
Published in
International Journal of Nanomedicine, May 2015
DOI 10.2147/ijn.s75936
Pubmed ID
Authors

Cindy Strehl, Timo Gaber, Lionel Maurizi, Martin Hahne, Roman Rauch, Paula Hoff, Margarethe Hofmann-Amtenbrink, Robin Poole, Heinrich Hofmann, Frank Buttgereit, Thomas Häupl

Abstract

Nanotechnology provides new opportunities in human medicine, mainly for diagnostic and therapeutic purposes. The autoimmune disease rheumatoid arthritis (RA) is often diagnosed after irreversible joint structural damage has occurred. There is an urgent need for a very early diagnosis of RA, which can be achieved by more sensitive imaging methods. Superparamagnetic iron oxide nanoparticles (SPION) are already used in medicine and therefore represent a promising tool for early diagnosis of RA. The focus of our work was to investigate any potentially negative effects resulting from the interactions of newly developed amino-functionalized amino-polyvinyl alcohol coated (a-PVA) SPION (a-PVA-SPION), that are used for imaging, with human immune cells. We analyzed the influence of a-PVA-SPION with regard to cell survival and cell activation in human whole blood in general, and in human monocytes and macrophages representative of professional phagocytes, using flow cytometry, multiplex suspension array, and transmission electron microscopy. We found no effect of a-PVA-SPION on the viability of human immune cells, but cytokine secretion was affected. We further demonstrated that the percentage of viable macrophages increased on exposure to a-PVA-SPION. This effect was even stronger when a-PVA-SPION were added very early in the differentiation process. Additionally, transmission electron microscopy analysis revealed that both monocytes and macrophages are able to endocytose a-PVA-SPION. Our findings demonstrate an interaction between human immune cells and a-PVA-SPION which needs to be taken into account when considering the use of a-PVA-SPION in human medicine.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 21%
Researcher 7 21%
Student > Bachelor 7 21%
Student > Master 6 18%
Student > Doctoral Student 2 6%
Other 2 6%
Unknown 2 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 18%
Pharmacology, Toxicology and Pharmaceutical Science 6 18%
Chemistry 5 15%
Medicine and Dentistry 4 12%
Agricultural and Biological Sciences 3 9%
Other 5 15%
Unknown 4 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2016.
All research outputs
#4,447,147
of 8,342,643 outputs
Outputs from International Journal of Nanomedicine
#1,011
of 1,827 outputs
Outputs of similar age
#115,439
of 210,382 outputs
Outputs of similar age from International Journal of Nanomedicine
#38
of 55 outputs
Altmetric has tracked 8,342,643 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,827 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,382 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.