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pH-sensitive poly(lactide-co-glycolide) nanoparticle composite microcapsules for oral delivery of insulin

Overview of attention for article published in International Journal of Nanomedicine, May 2015
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About this Attention Score

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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
34 Dimensions

Readers on

mendeley
75 Mendeley
Title
pH-sensitive poly(lactide-co-glycolide) nanoparticle composite microcapsules for oral delivery of insulin
Published in
International Journal of Nanomedicine, May 2015
DOI 10.2147/ijn.s81715
Pubmed ID
Authors

Shaoping Sun, Hiromitsu Yamamoto, Yoshiaki Kawashima, Fude Cui, Pengfei Yan, Na Liang

Abstract

This study proposes a new concept of pH-sensitive poly(lactide-co-glycolide) (PLGA) nanoparticle composite microcapsules for oral delivery of insulin. Firstly, insulin-sodium oleate complex was prepared by the hydrophobic ion pairing method and then encapsulated into PLGA nanoparticles by the emulsion solvent diffusion method. In order to reduce the burst release of insulin from PLGA nanoparticles and deliver insulin to specific gastrointestinal regions, hence to enhance bioavailability of insulin, the PLGA nanoparticles were further encapsulated into Eudragit(®) FS 30D to prepare PLGA nanoparticle composite microcapsules by organic spray-drying method. The preparation was evaluated in vitro and in vivo, and the absorption mechanism was discussed. The in vitro drug release studies revealed that the drug release was pH dependent, and the in vivo results demonstrated that the formulation of PLGA nanoparticle composite microcapsules was an effective candidate for oral insulin delivery.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 49 65%
Student > Master 5 7%
Student > Ph. D. Student 4 5%
Student > Doctoral Student 1 1%
Lecturer 1 1%
Other 3 4%
Unknown 12 16%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 42 56%
Biochemistry, Genetics and Molecular Biology 11 15%
Medicine and Dentistry 3 4%
Chemical Engineering 2 3%
Agricultural and Biological Sciences 2 3%
Other 2 3%
Unknown 13 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2015.
All research outputs
#2,512,557
of 5,090,406 outputs
Outputs from International Journal of Nanomedicine
#468
of 1,342 outputs
Outputs of similar age
#85,204
of 161,909 outputs
Outputs of similar age from International Journal of Nanomedicine
#25
of 56 outputs
Altmetric has tracked 5,090,406 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,342 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,909 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.