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Clinical, physiological, and radiological features of asthma–chronic obstructive pulmonary disease overlap syndrome

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, May 2015
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Citations

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59 Mendeley
Title
Clinical, physiological, and radiological features of asthma–chronic obstructive pulmonary disease overlap syndrome
Published in
International Journal of Chronic Obstructive Pulmonary Disease, May 2015
DOI 10.2147/copd.s80022
Pubmed ID
Authors

Yuji Tada, Toshio Suzuki, Naoko Kawata, Yukiko Matsuura, Jun Ikari, Yasunori Kasahara, Koichiro Tatsumi

Abstract

Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is associated with rapid decline in lung function, poorer health-related quality-of-life outcomes, and frequent exacerbations, compared to COPD alone. Although the numbers of patients with ACOS have increased, there is little established evidence regarding diagnostic criteria and treatment options. Thus, the aim of our study was to clarify the clinical, physiological, and radiological features of patients with ACOS. We examined a total of 100 patients with COPD and 40 patients with ACOS, who were selected based on clinical criteria. All patients underwent baseline testing, including a COPD assessment test, pulmonary function tests, and multidetector row computed tomography imaging. Percentage of low attenuation volume, percentage of wall area, and percentage of total cross-sectional area of pulmonary vessels less than 5 mm(2) (%CSA <5) were determined using multidetector row computed tomography. ACOS patients were administered a fixed dose of budesonide/formoterol (160/4.5 μg, two inhalations; twice daily) for 12 weeks, after which the ACOS patients underwent multidetector row computed tomography to measure the same parameters. At baseline, the ACOS patients and COPD patients had a similar degree of airflow limitation, vital capacity, and residual volume. ACOS patients had higher COPD assessment test scores, percentage of wall area, and %CSA <5 than COPD patients. Compared to baseline, budesonide/formoterol treatment significantly increased the forced expiratory volume in 1 second and decreased the degree of airway wall thickness (percentage of wall area) as well as pulmonary microvascular density (%CSA <5) in ACOS patients. Our results suggest that ACOS is characterized by an airway lesion-dominant phenotype, in contrast to COPD. Higher %CSA <5 might be a characteristic feature of ACOS.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 17%
Other 7 12%
Researcher 7 12%
Professor > Associate Professor 6 10%
Student > Doctoral Student 5 8%
Other 11 19%
Unknown 13 22%
Readers by discipline Count As %
Medicine and Dentistry 35 59%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Nursing and Health Professions 2 3%
Computer Science 2 3%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 0 0%
Unknown 15 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2016.
All research outputs
#18,410,971
of 22,805,349 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,897
of 2,351 outputs
Outputs of similar age
#192,628
of 264,354 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#45
of 52 outputs
Altmetric has tracked 22,805,349 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,351 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,354 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.