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Activation of mTOR: a culprit of Alzheimer’s disease?

Overview of attention for article published in Neuropsychiatric Disease and Treatment, April 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#16 of 2,209)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
9 news outlets
twitter
4 tweeters
facebook
4 Facebook pages

Citations

dimensions_citation
63 Dimensions

Readers on

mendeley
133 Mendeley
Title
Activation of mTOR: a culprit of Alzheimer’s disease?
Published in
Neuropsychiatric Disease and Treatment, April 2015
DOI 10.2147/ndt.s75717
Pubmed ID
Authors

Zhiyou Cai, Yingjun Zhou, Ming Xiao, Liang-Jun Yan, Wenbo He

Abstract

Alzheimer's disease (AD) is characterized by cognitive impairment in clinical presentation, and by β-amyloid (Aβ) production and the hyper-phosphorylation of tau in basic research. More highlights demonstrate that the activation of the mammalian target of rapamycin (mTOR) enhances Aβ generation and deposition by modulating amyloid precursor protein (APP) metabolism and upregulating β- and γ-secretases. mTOR, an inhibitor of autophagy, decreases Aβ clearance by scissoring autophagy function. mTOR regulates Aβ generation or Aβ clearance by regulating several key signaling pathways, including phosphoinositide 3-kinase (PI3-K)/protein kinase B (Akt), glycogen synthase kinase 3 [GSK-3], AMP-activated protein kinase (AMPK), and insulin/insulin-like growth factor 1 (IGF-1). The activation of mTOR is also a contributor to aberrant hyperphosphorylated tau. Rapamycin, the inhibitor of mTOR, may mitigate cognitive impairment and inhibit the pathologies associated with amyloid plaques and neurofibrillary tangles by promoting autophagy. Furthermore, the upstream and downstream components of mTOR signaling are involved in the pathogenesis and progression of AD. Hence, inhibiting the activation of mTOR may be an important therapeutic target for AD.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Mexico 1 <1%
Spain 1 <1%
Unknown 130 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 28%
Researcher 21 16%
Student > Master 19 14%
Student > Bachelor 14 11%
Student > Doctoral Student 9 7%
Other 21 16%
Unknown 12 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 21%
Biochemistry, Genetics and Molecular Biology 24 18%
Medicine and Dentistry 19 14%
Neuroscience 18 14%
Chemistry 6 5%
Other 17 13%
Unknown 21 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2018.
All research outputs
#211,229
of 13,079,903 outputs
Outputs from Neuropsychiatric Disease and Treatment
#16
of 2,209 outputs
Outputs of similar age
#4,699
of 231,639 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#1
of 46 outputs
Altmetric has tracked 13,079,903 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,209 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,639 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.