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Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma

Overview of attention for article published in Drug Design, Development and Therapy, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter
patent
3 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
85 Dimensions

Readers on

mendeley
173 Mendeley
Title
Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma
Published in
Drug Design, Development and Therapy, April 2015
DOI 10.2147/dddt.s79592
Pubmed ID
Authors

Fang Zhang, Chun-lei xu, Chun-mei Liu

Abstract

Gliomas are amongst the most insidious and destructive types of brain cancer and are associated with a poor prognosis, frequent recurrences, and extremely high lethality despite combination treatment of surgery, radiotherapy, and chemotherapy. The existence of the blood-brain barrier (BBB) restricts the delivery of therapeutic molecules into the brain and offers the clinical efficacy of many pharmaceuticals that have been demonstrated to be effective for other kinds of tumors. This challenge emphasizes the need to be able to deliver drugs effectively across the BBB to reach the brain parenchyma. Enhancement of the permeability of the BBB and being able to transport drugs across it has been shown to be a promising strategy to improve drug absorption and treatment efficacy. This review highlights the innovative technologies that have been introduced to enhance the permeability of the BBB and to obtain an optimal distribution and concentration of drugs in the brain to treat gliomas, such as nanotechniques, hyperthermia techniques, receptor-mediated transport, cell-penetrating peptides, and cell-mediated delivery.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Portugal 1 <1%
France 1 <1%
Canada 1 <1%
Unknown 169 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 17%
Student > Master 26 15%
Researcher 22 13%
Student > Bachelor 20 12%
Student > Doctoral Student 11 6%
Other 32 18%
Unknown 33 19%
Readers by discipline Count As %
Medicine and Dentistry 23 13%
Biochemistry, Genetics and Molecular Biology 21 12%
Agricultural and Biological Sciences 21 12%
Pharmacology, Toxicology and Pharmaceutical Science 15 9%
Chemistry 13 8%
Other 41 24%
Unknown 39 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2019.
All research outputs
#2,010,958
of 20,867,471 outputs
Outputs from Drug Design, Development and Therapy
#89
of 1,936 outputs
Outputs of similar age
#28,858
of 247,752 outputs
Outputs of similar age from Drug Design, Development and Therapy
#5
of 79 outputs
Altmetric has tracked 20,867,471 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,936 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,752 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.