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Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia

Overview of attention for article published in Neuropsychiatric Disease and Treatment, March 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#32 of 2,466)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
6 news outlets
blogs
1 blog
twitter
6 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
21 Dimensions

Readers on

mendeley
52 Mendeley
Title
Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia
Published in
Neuropsychiatric Disease and Treatment, March 2015
DOI 10.2147/ndt.s80746
Pubmed ID
Authors

Martin Valis, Jiri Masopust, Ctirad Andrys, Jan Bazant, Oldrich Vysata, Kamil Kuca

Abstract

Encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDA-R) is classified as an autoimmune disorder with psychotic symptoms, which are frequently dominant. However, it remains unclear how frequently NMDA-R antibodies lead to a condition that mimics psychosis and first-episode schizophrenia. In our work, we investigated the presence of antibodies against NMDA-R in patients with first-episode psychosis (FEP) in comparison with healthy volunteers. This study included 50 antipsychotic-naïve patients with FEP (including 21 women) and 50 healthy volunteers (including 21 women). The mean age of the patients was 27.4 (±7.4) years and that of the healthy controls was 27.0 (±7.3) years. Antibodies against NMDA-R in the serum were detected by immunofluorescence. None of the investigated patients with an FEP and none of the healthy controls showed positive antibodies against NMDA-Rs. According to results of studies, a small proportion of patients with an FEP possess antibodies against NMDA-R. However, the extent to which this finding contributes to the etiopathogenesis of the response to antipsychotic medication and whether immunomodulatory therapy is indicated in these cases remains uncertain.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Bangladesh 1 2%
Unknown 50 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 15%
Researcher 8 15%
Student > Bachelor 7 13%
Other 7 13%
Student > Postgraduate 6 12%
Other 10 19%
Unknown 6 12%
Readers by discipline Count As %
Medicine and Dentistry 21 40%
Neuroscience 7 13%
Agricultural and Biological Sciences 7 13%
Psychology 5 10%
Social Sciences 2 4%
Other 2 4%
Unknown 8 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 64. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2017.
All research outputs
#298,983
of 14,365,000 outputs
Outputs from Neuropsychiatric Disease and Treatment
#32
of 2,466 outputs
Outputs of similar age
#5,920
of 234,074 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#1
of 46 outputs
Altmetric has tracked 14,365,000 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,466 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,074 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.