Title |
Augmentation with antidepressants in schizophrenia treatment: benefit or risk
|
---|---|
Published in |
Neuropsychiatric Disease and Treatment, March 2015
|
DOI | 10.2147/ndt.s62266 |
Pubmed ID | |
Authors |
Ye-Meng Mao, Ming-Dao Zhang |
Abstract |
We focused on the application of antidepressants in schizophrenia treatment in this review. Augmentation of antidepressants with antipsychotics is a common clinical practice to treat resistant symptoms in schizophrenia, including depressive symptoms, negative symptoms, comorbid obsessive-compulsive symptoms, and other psychotic manifestations. However, recent systematic review of the clinical effects of antidepressants is lacking. In this review, we have selected and summarized current literature on the use of antidepressants in patients with schizophrenia; the patterns of use and effectiveness, as well as risks and drug-drug interactions of this clinical practice are discussed in detail, with particular emphasis on the treatment of depressive symptoms in schizophrenia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 132 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 26 | 20% |
Student > Master | 14 | 11% |
Researcher | 13 | 10% |
Student > Doctoral Student | 12 | 9% |
Student > Ph. D. Student | 11 | 8% |
Other | 20 | 15% |
Unknown | 37 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 40 | 30% |
Pharmacology, Toxicology and Pharmaceutical Science | 16 | 12% |
Psychology | 10 | 8% |
Agricultural and Biological Sciences | 5 | 4% |
Neuroscience | 5 | 4% |
Other | 12 | 9% |
Unknown | 45 | 34% |