Title |
Residual disease and risk factors in patients with high-grade cervical intraepithelial neoplasia and positive margins after initial conization
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Published in |
Therapeutics and Clinical Risk Management, May 2015
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DOI | 10.2147/tcrm.s81802 |
Pubmed ID | |
Authors |
Yunfeng Fu, Chen Chen, Suwen Feng, Xiaodong Cheng, Xinyu Wang, Xing Xie, Weiguo Lü |
Abstract |
The purpose of this study was to determine the clinicopathologic predictors of residual disease in patients with high-grade cervical intraepithelial neoplasia (CIN) and margin involvement after initial conization. Data from 145 patients who underwent subsequent surgery for high-grade CIN with positive margins were retrospectively analyzed. After subsequent surgery, residual disease was diagnosed in 47 (34.2%) patients, of whom five had invasive cervical carcinoma, 31 had CIN 3, nine had CIN 2, and two had CIN 1. Multivariate analysis revealed that only age ≥35 years (P=0.033), major abnormal cytology (P=0.002), and pre-cone high-risk human papillomavirus load ≥300 relative light units (P=0.011) were significant factors associated with residual disease. Age ≥35 years, major abnormal cytology, and pre-cone high-risk human papillomavirus load ≥300 relative light units were the only significant factors predicting post-cone residual disease. Appropriate application of these predictive factors may avoid delayed treatment and overtreatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 3 | 12% |
Student > Doctoral Student | 2 | 8% |
Student > Bachelor | 2 | 8% |
Student > Master | 2 | 8% |
Researcher | 2 | 8% |
Other | 2 | 8% |
Unknown | 13 | 50% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 42% |
Sports and Recreations | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Unknown | 13 | 50% |