| Title |
Brain in flames – animal models of psychosis: utility and limitations
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, May 2015
|
| DOI | 10.2147/ndt.s65564 |
| Pubmed ID | |
| Authors |
Daniele Mattei, Regina Schweibold, Susanne A Wolf |
| Abstract |
The neurodevelopmental hypothesis of schizophrenia posits that schizophrenia is a psychopathological condition resulting from aberrations in neurodevelopmental processes caused by a combination of environmental and genetic factors which proceed long before the onset of clinical symptoms. Many studies discuss an immunological component in the onset and progression of schizophrenia. We here review studies utilizing animal models of schizophrenia with manipulations of genetic, pharmacologic, and immunological origin. We focus on the immunological component to bridge the studies in terms of evaluation and treatment options of negative, positive, and cognitive symptoms. Throughout the review we link certain aspects of each model to the situation in human schizophrenic patients. In conclusion we suggest a combination of existing models to better represent the human situation. Moreover, we emphasize that animal models represent defined single or multiple symptoms or hallmarks of a given disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 2 | 2% |
| United Kingdom | 1 | 1% |
| Unknown | 89 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 21% |
| Student > Bachelor | 14 | 15% |
| Researcher | 12 | 13% |
| Student > Master | 10 | 11% |
| Student > Doctoral Student | 4 | 4% |
| Other | 13 | 14% |
| Unknown | 20 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 18 | 20% |
| Agricultural and Biological Sciences | 14 | 15% |
| Medicine and Dentistry | 10 | 11% |
| Psychology | 6 | 7% |
| Biochemistry, Genetics and Molecular Biology | 5 | 5% |
| Other | 8 | 9% |
| Unknown | 31 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2015.
All research outputs
#15,879,822
of 25,584,565 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,489
of 3,120 outputs
Outputs of similar age
#145,918
of 279,338 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#45
of 72 outputs
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