| Title |
Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials
|
|---|---|
| Published in |
Journal of Pain Research, May 2018
|
| DOI | 10.2147/jpr.s160255 |
| Pubmed ID | |
| Authors |
Diana S Meske, Oluwadolapo D Lawal, Harrison Elder, Valerie Langberg, Florence Paillard, Nathaniel Katz |
| Abstract |
Opioids have been used for millennia for the treatment of pain. However, the long-term efficacy of opioids to treat chronic non-cancer pain continues to be debated. To evaluate opioids' efficacy in chronic non-cancer pain, we performed a meta-analysis of published clinical trials for μ-opioid receptor agonists performed for US Food and Drug Administration approval. MEDLINE and Cochrane trial register were searched for enriched enrollment randomized withdrawal studies (before June 2016). Selection criteria included: adults, ≥10 subjects per arm, any chronic pain condition, double-blind treatment period lasting ≥12 weeks, and all μ-agonist opioids approved in the USA. Fifteen studies met criteria. Opioid efficacy was statistically significant (p<0.001) versus placebo for pain intensity (standardized mean difference: -0.416), ≥30% and ≥50% improvement in pain (risk difference: 0.166 and 0.137), patient global impression of change (0.163), and patient global assessment of study medication (0.194). There were minor benefits on physical function and no effect on mental function. Opioids are efficacious in the treatment of chronic non-cancer pain for up to 3 months in randomized controlled trials. This should be considered, alongside data on opioid safety, in the use of opioids for the treatment of chronic pain. |
X Demographics
The data shown below were collected from the profiles of 212 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 105 | 50% |
| Australia | 3 | 1% |
| United Kingdom | 3 | 1% |
| Canada | 2 | <1% |
| Spain | 1 | <1% |
| Ireland | 1 | <1% |
| Comoros | 1 | <1% |
| Côte d'Ivoire | 1 | <1% |
| Georgia | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 94 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 188 | 89% |
| Practitioners (doctors, other healthcare professionals) | 16 | 8% |
| Scientists | 7 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 87 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 16% |
| Student > Bachelor | 9 | 10% |
| Student > Ph. D. Student | 8 | 9% |
| Other | 8 | 9% |
| Student > Doctoral Student | 6 | 7% |
| Other | 18 | 21% |
| Unknown | 24 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 31% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 9% |
| Psychology | 5 | 6% |
| Nursing and Health Professions | 4 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Other | 10 | 11% |
| Unknown | 30 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 172. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2024.
All research outputs
#238,808
of 25,880,422 outputs
Outputs from Journal of Pain Research
#32
of 2,006 outputs
Outputs of similar age
#5,359
of 341,919 outputs
Outputs of similar age from Journal of Pain Research
#4
of 54 outputs
Altmetric has tracked 25,880,422 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,006 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.