↓ Skip to main content

Dove Medical Press

Article Metrics

Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials

Overview of attention for article published in Journal of Pain Research, May 2018
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#18 of 1,214)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

twitter
241 tweeters
facebook
2 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
21 Dimensions

Readers on

mendeley
49 Mendeley
Title
Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials
Published in
Journal of Pain Research, May 2018
DOI 10.2147/jpr.s160255
Pubmed ID
Authors

Diana S Meske, Oluwadolapo Lawal, Harrison Elder, Valerie Langberg, Florence Paillard, Nathaniel Katz

Abstract

Opioids have been used for millennia for the treatment of pain. However, the long-term efficacy of opioids to treat chronic non-cancer pain continues to be debated. To evaluate opioids' efficacy in chronic non-cancer pain, we performed a meta-analysis of published clinical trials for μ-opioid receptor agonists performed for US Food and Drug Administration approval. MEDLINE and Cochrane trial register were searched for enriched enrollment randomized withdrawal studies (before June 2016). Selection criteria included: adults, ≥10 subjects per arm, any chronic pain condition, double-blind treatment period lasting ≥12 weeks, and all μ-agonist opioids approved in the USA. Fifteen studies met criteria. Opioid efficacy was statistically significant (p<0.001) versus placebo for pain intensity (standardized mean difference: -0.416), ≥30% and ≥50% improvement in pain (risk difference: 0.166 and 0.137), patient global impression of change (0.163), and patient global assessment of study medication (0.194). There were minor benefits on physical function and no effect on mental function. Opioids are efficacious in the treatment of chronic non-cancer pain for up to 3 months in randomized controlled trials. This should be considered, alongside data on opioid safety, in the use of opioids for the treatment of chronic pain.

Twitter Demographics

The data shown below were collected from the profiles of 241 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 18%
Other 7 14%
Student > Bachelor 7 14%
Student > Ph. D. Student 6 12%
Student > Master 4 8%
Other 11 22%
Unknown 5 10%
Readers by discipline Count As %
Medicine and Dentistry 23 47%
Pharmacology, Toxicology and Pharmaceutical Science 7 14%
Psychology 3 6%
Biochemistry, Genetics and Molecular Biology 2 4%
Nursing and Health Professions 2 4%
Other 3 6%
Unknown 9 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 174. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2020.
All research outputs
#108,807
of 15,856,755 outputs
Outputs from Journal of Pain Research
#18
of 1,214 outputs
Outputs of similar age
#4,084
of 279,243 outputs
Outputs of similar age from Journal of Pain Research
#1
of 30 outputs
Altmetric has tracked 15,856,755 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,214 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,243 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.