Title |
Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond
|
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Published in |
Vascular Health and Risk Management, June 2015
|
DOI | 10.2147/vhrm.s55630 |
Pubmed ID | |
Authors |
Jagdeep SS Singh, Chim C Lang |
Abstract |
Heart failure remains a major concern across the globe as life expectancies and delivery of health care continue to improve. There has been a dearth of new developments in heart failure therapies in the last decade until last year, with the release of the results from the PARADIGM-HF Trial heralding the arrival of a promising new class of drug, ie, the angiotensin receptor-neprilysin inhibitor. In this review, we discuss the evolution of our incremental understanding of the neurohormonal mechanisms involved in the pathophysiology of heart failure, which has led to our success in modulating its various pathways. We start by examining the renin-angiotensin-aldosterone system, followed by the challenges of modulating the natriuretic peptide system. We then delve deeper into the pharmacology and mechanisms by which angiotensin receptor-neprilysin inhibitors achieve their significant cardiovascular benefits. Finally, we also consider the potential application of this new class of drug in other areas, such as heart failure with preserved ejection fraction, hypertension, patients with renal impairment, and following myocardial infarction. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Members of the public | 2 | 40% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
United Kingdom | 1 | 1% |
Unknown | 70 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 16% |
Student > Bachelor | 9 | 12% |
Student > Ph. D. Student | 9 | 12% |
Student > Master | 7 | 10% |
Student > Doctoral Student | 6 | 8% |
Other | 15 | 21% |
Unknown | 15 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 49% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Nursing and Health Professions | 6 | 8% |
Agricultural and Biological Sciences | 4 | 5% |
Neuroscience | 2 | 3% |
Other | 5 | 7% |
Unknown | 14 | 19% |