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Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond

Overview of attention for article published in Vascular Health and Risk Management, June 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
16 Dimensions

Readers on

mendeley
65 Mendeley
Title
Angiotensin receptor-neprilysin inhibitors: clinical potential in heart failure and beyond
Published in
Vascular Health and Risk Management, June 2015
DOI 10.2147/vhrm.s55630
Pubmed ID
Authors

Chim Lang, Jagdeep Singh

Abstract

Heart failure remains a major concern across the globe as life expectancies and delivery of health care continue to improve. There has been a dearth of new developments in heart failure therapies in the last decade until last year, with the release of the results from the PARADIGM-HF Trial heralding the arrival of a promising new class of drug, ie, the angiotensin receptor-neprilysin inhibitor. In this review, we discuss the evolution of our incremental understanding of the neurohormonal mechanisms involved in the pathophysiology of heart failure, which has led to our success in modulating its various pathways. We start by examining the renin-angiotensin-aldosterone system, followed by the challenges of modulating the natriuretic peptide system. We then delve deeper into the pharmacology and mechanisms by which angiotensin receptor-neprilysin inhibitors achieve their significant cardiovascular benefits. Finally, we also consider the potential application of this new class of drug in other areas, such as heart failure with preserved ejection fraction, hypertension, patients with renal impairment, and following myocardial infarction.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
United Kingdom 1 2%
Unknown 62 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 17%
Student > Ph. D. Student 8 12%
Student > Bachelor 8 12%
Student > Master 7 11%
Student > Doctoral Student 6 9%
Other 15 23%
Unknown 10 15%
Readers by discipline Count As %
Medicine and Dentistry 33 51%
Pharmacology, Toxicology and Pharmaceutical Science 7 11%
Nursing and Health Professions 6 9%
Agricultural and Biological Sciences 4 6%
Neuroscience 2 3%
Other 5 8%
Unknown 8 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2021.
All research outputs
#10,646,047
of 19,249,286 outputs
Outputs from Vascular Health and Risk Management
#328
of 681 outputs
Outputs of similar age
#102,765
of 246,164 outputs
Outputs of similar age from Vascular Health and Risk Management
#10
of 23 outputs
Altmetric has tracked 19,249,286 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 681 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,164 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.