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Novel aspects of pathogenesis and regeneration mechanisms in COPD

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, June 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
44 Dimensions

Readers on

mendeley
158 Mendeley
Title
Novel aspects of pathogenesis and regeneration mechanisms in COPD
Published in
International Journal of Chronic Obstructive Pulmonary Disease, June 2015
DOI 10.2147/copd.s82518
Pubmed ID
Authors

Ruta Aldonyte, Edvardas Bagdonas, Jovile Raudoniute, Ieva Bruzauskaite

Abstract

Chronic obstructive pulmonary disease (COPD), a major cause of death and morbidity worldwide, is characterized by expiratory airflow limitation that is not fully reversible, deregulated chronic inflammation, and emphysematous destruction of the lungs. Despite the fact that COPD is a steadily growing global healthcare problem, the conventional therapies remain palliative, and regenerative approaches for disease management are not available yet. We aim to provide an overview of key reviews, experimental, and clinical studies addressing lung emphysema development and repair mechanisms published in the past decade. Novel aspects discussed herein include integral revision of the literature focused on lung microflora changes in COPD, autoimmune component of the disease, and environmental risk factors other than cigarette smoke. The time span of studies on COPD, including emphysema, chronic bronchitis, and asthmatic bronchitis, covers almost 200 years, and several crucial mechanisms of COPD pathogenesis are described and studied. However, we still lack the holistic understanding of COPD development and the exact picture of the time-course and interplay of the events during stable, exacerbated, corticosteroid-treated COPD states, and transitions in-between. Several generally recognized mechanisms will be discussed shortly herein, ie, unregulated inflammation, proteolysis/antiproteolysis imbalance, and destroyed repair mechanisms, while novel topics such as deviated microbiota, air pollutants-related damage, and autoimmune process within the lung tissue will be discussed more extensively. Considerable influx of new data from the clinic, in vivo and in vitro studies stimulate to search for novel concise explanation and holistic understanding of COPD nowadays.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Colombia 1 <1%
Unknown 156 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 32 20%
Student > Bachelor 25 16%
Researcher 23 15%
Student > Ph. D. Student 23 15%
Student > Doctoral Student 11 7%
Other 27 17%
Unknown 17 11%
Readers by discipline Count As %
Medicine and Dentistry 49 31%
Agricultural and Biological Sciences 26 16%
Biochemistry, Genetics and Molecular Biology 21 13%
Immunology and Microbiology 13 8%
Nursing and Health Professions 6 4%
Other 19 12%
Unknown 24 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2015.
All research outputs
#2,386,201
of 5,234,334 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#258
of 642 outputs
Outputs of similar age
#81,824
of 176,386 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#16
of 56 outputs
Altmetric has tracked 5,234,334 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 642 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,386 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.