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Gold nanoparticles allow detection of early-stage edema in mice via computed tomography imaging

Overview of attention for article published in International Journal of Nanomedicine, June 2015
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Mentioned by

twitter
3 tweeters

Citations

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9 Dimensions

Readers on

mendeley
16 Mendeley
Title
Gold nanoparticles allow detection of early-stage edema in mice via computed tomography imaging
Published in
International Journal of Nanomedicine, June 2015
DOI 10.2147/ijn.s77383
Pubmed ID
Authors

Jenny Domey, Ulf Teichgräber, Ingrid Hilger

Abstract

Due to their high X-ray attenuation, gold nanoparticles (GNPs) emerged as preclinical contrast agents by giving high vasculature contrast. For this reason, GNPs are regularly applied for computed tomography (CT) imaging of tumors but not for the visualization of inflammation. The aim of this study was to evaluate the biocompatibility and applicability of preclinical GNPs (AuroVist™) of two different sizes (1.9 nm and 15 nm) for the detection of inflammation-associated phagocytes in early-stage edema. Both GNP variants were stable under in vitro conditions and achieved high micro-CT (mCT) contrast after embedment into agarose. Fifteen-nanometer GNPs were detected after uptake into macrophages via mCT imaging exhibiting higher X-ray contrast than cells treated with 1.9 nm GNPs and untreated ones. Both 1.9 nm and 15 nm GNPs exhibited good biocompatibility on murine macrophages according to ATP and cellular dehydrogenase levels. Reactive oxygen species levels produced by phagocytic cells decreased significantly (P≤0.05) after co-incubation with GNPs regardless of the size of the nanoparticle (NP) in comparison to untreated control cells. In vivo mCT studies of inflammation imaging revealed that GNPs with a diameter of 15 nm accumulated within subcutaneous edema 2 hours after injection with a maximum signaling 8 hours postinjection and could be detected up to 48 hours within the edema region. In contrast, 1.9 nm GNPs were not shown to accumulate at the site of the inflammation region and were mostly excreted via the renal system 2-4 hours after injection. In conclusion, our study demonstrated that both GNP variants (1.9 nm and 15 nm) were stable and biocompatible under in vitro conditions. However, only 15 nm NPs have the potential as contrast agent for phagocyte labeling and applications in CT imaging of inflammation on a cellular level.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 25%
Student > Master 4 25%
Student > Ph. D. Student 3 19%
Student > Postgraduate 2 13%
Professor > Associate Professor 1 6%
Other 0 0%
Unknown 2 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 19%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Materials Science 2 13%
Medicine and Dentistry 2 13%
Agricultural and Biological Sciences 2 13%
Other 2 13%
Unknown 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2015.
All research outputs
#2,563,140
of 5,180,928 outputs
Outputs from International Journal of Nanomedicine
#488
of 1,372 outputs
Outputs of similar age
#90,100
of 175,003 outputs
Outputs of similar age from International Journal of Nanomedicine
#39
of 89 outputs
Altmetric has tracked 5,180,928 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,372 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,003 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.