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Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells

Overview of attention for article published in International Journal of Nanomedicine, June 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (75th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

twitter
5 tweeters
patent
1 patent

Citations

dimensions_citation
70 Dimensions

Readers on

mendeley
76 Mendeley
Title
Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
Published in
International Journal of Nanomedicine, June 2015
DOI 10.2147/ijn.s80349
Pubmed ID
Authors

Ravi Singh, Jessica Swanner, Jade Mims, Steven Akman, Cristina Furdui, Suzy Torti, David Carroll

Abstract

Identification of differential sensitivity of cancer cells as compared to normal cells has the potential to reveal a therapeutic window for the use of silver nanoparticles (AgNPs) as a therapeutic agent for cancer therapy. Exposure to AgNPs is known to cause dose-dependent toxicities, including induction of oxidative stress and DNA damage, which can lead to cell death. Triple-negative breast cancer (TNBC) subtypes are more vulnerable to agents that cause oxidative stress and DNA damage than are other breast cancer subtypes. We hypothesized that TNBC may be susceptible to AgNP cytotoxicity, a potential vulnerability that could be exploited for the development of new therapeutic agents. We show that AgNPs are highly cytotoxic toward TNBC cells at doses that have little effect on nontumorigenic breast cells or cells derived from liver, kidney, and monocyte lineages. AgNPs induced more DNA and oxidative damage in TNBC cells than in other breast cells. In vitro and in vivo studies showed that AgNPs reduce TNBC growth and improve radiation therapy. These studies show that unmodified AgNPs act as a self-therapeutic agent with a combination of selective cytotoxicity and radiation dose-enhancement effects in TNBC at doses that are nontoxic to noncancerous breast and other cells.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Korea, Republic of 1 1%
Mexico 1 1%
Germany 1 1%
Unknown 72 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 28%
Student > Master 12 16%
Student > Bachelor 8 11%
Researcher 6 8%
Student > Postgraduate 4 5%
Other 10 13%
Unknown 15 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 16%
Medicine and Dentistry 10 13%
Chemistry 9 12%
Agricultural and Biological Sciences 7 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 11 14%
Unknown 23 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2018.
All research outputs
#3,667,105
of 14,807,872 outputs
Outputs from International Journal of Nanomedicine
#278
of 2,827 outputs
Outputs of similar age
#56,241
of 235,050 outputs
Outputs of similar age from International Journal of Nanomedicine
#4
of 97 outputs
Altmetric has tracked 14,807,872 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,827 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,050 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.