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Dosing of U-100 insulin and associated outcomes among Medicare enrollees with type 1 or type 2 diabetes

Overview of attention for article published in Clinical Interventions in Aging, January 2015
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1 tweeter
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Citations

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44 Mendeley
Title
Dosing of U-100 insulin and associated outcomes among Medicare enrollees with type 1 or type 2 diabetes
Published in
Clinical Interventions in Aging, January 2015
DOI 10.2147/cia.s76398
Pubmed ID
Authors

Maureen Lage, Cynthia Brusko, Kate Van Brunt, Bradley Curtis, Elizabeth Eby

Abstract

To examine costs, resource utilization, adherence, and hypoglycemic events among various doses of U-100 insulin regimens among elderly patients (age ≥65 years) diagnosed with diabetes. Truven Health Analytics Medicare databases from January 1, 2008 through December 31, 2011 were utilized. General linear models with a gamma distribution and log link were used to examine costs, while logistic and negative binomial regressions were used to examine resource utilization and hypoglycemic events. Analyses controlled for patient characteristics, pre-period comorbidities, general health, and use of antidiabetic medications as well as index dose of insulin. All-cause inpatient, emergency room, and outpatients costs, as well as diabetes-related inpatient costs, were highest among individuals who were treated with an index dose of 10-100 units/day followed by >300 units/day, while drug costs and total costs generally increased as index dosage increased. Resource utilization generally followed the same pattern as costs, with number of office visits increasing as the dose increased and the highest hospital length of stay, number of hospitalizations, number of emergency room visits, and number of diabetes-related hospitalizations were generally highest among those in the lowest and highest index dose cohorts. Compared to patients who initiated with an index dose of 10-100 units/day, all other patients were significantly less likely to achieve an adherence threshold of 80% based upon index dose range, and while those with an index dose of >100-150 units/day were significantly more likely to experience a hypoglycemic event. These results suggest that, for elderly individuals with diabetes, there is a higher patient burden among those who receive the lowest and highest insulin doses.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 14%
Researcher 6 14%
Other 5 11%
Student > Bachelor 5 11%
Student > Ph. D. Student 5 11%
Other 6 14%
Unknown 11 25%
Readers by discipline Count As %
Medicine and Dentistry 10 23%
Nursing and Health Professions 7 16%
Pharmacology, Toxicology and Pharmaceutical Science 6 14%
Psychology 2 5%
Social Sciences 2 5%
Other 3 7%
Unknown 14 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2015.
All research outputs
#17,763,547
of 22,813,792 outputs
Outputs from Clinical Interventions in Aging
#1,297
of 1,839 outputs
Outputs of similar age
#241,867
of 353,106 outputs
Outputs of similar age from Clinical Interventions in Aging
#92
of 143 outputs
Altmetric has tracked 22,813,792 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,839 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,106 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 143 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.