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Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

Overview of attention for article published in Drug Design, Development and Therapy, June 2015
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Mentioned by

twitter
1 tweeter
facebook
1 Facebook page

Citations

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32 Dimensions

Readers on

mendeley
21 Mendeley
Title
Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells
Published in
Drug Design, Development and Therapy, June 2015
DOI 10.2147/dddt.s84448
Pubmed ID
Authors

Huaifeng Li, Xuan Wang, Shanshan Xiang, Yunping Hu, Lin Jiang, Yijun Shu, Maolan Li, Xiangsong Wu, Fei Zhang, Yuanyuan Ye, Hao Weng, Runfa Bao, Yang Cao, Wei Lu, Qian Dong, Yingbin Liu

Abstract

Oleanolic acid (OA), a naturally occurring triterpenoid, exhibits potential antitumor activity in many tumor cell lines. Gallbladder carcinoma is the most common malignancy of the biliary tract, and is a highly aggressive tumor with an extremely poor prognosis. Unfortunately, the effects of OA on gallbladder carcinoma are unknown. In this study, we investigated the effects of OA on gallbladder cancer cells and the underlying mechanism. The results showed that OA inhibits proliferation of gallbladder cancer cells in a dose-dependent and time-dependent manner on MTT and colony formation assay. A flow cytometry assay revealed apoptosis and G0/G1 phase arrest in GBC-SD and NOZ cells. Western blot analysis and a mitochondrial membrane potential assay demonstrated that OA functions through the mitochondrial apoptosis pathway. Moreover, this drug inhibited tumor growth in nude mice carrying subcutaneous NOZ tumor xenografts. These data suggest that OA inhibits proliferation of gallbladder cancer cells by regulating apoptosis and the cell cycle process. Thus, OA may be a promising drug for adjuvant chemotherapy in gallbladder carcinoma.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Student > Master 3 14%
Student > Ph. D. Student 2 10%
Student > Bachelor 2 10%
Student > Doctoral Student 1 5%
Other 1 5%
Unknown 8 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 19%
Medicine and Dentistry 3 14%
Agricultural and Biological Sciences 2 10%
Immunology and Microbiology 1 5%
Chemical Engineering 1 5%
Other 0 0%
Unknown 10 48%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2016.
All research outputs
#5,310,497
of 7,084,078 outputs
Outputs from Drug Design, Development and Therapy
#487
of 937 outputs
Outputs of similar age
#153,749
of 222,552 outputs
Outputs of similar age from Drug Design, Development and Therapy
#75
of 136 outputs
Altmetric has tracked 7,084,078 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 937 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,552 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.