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Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies

Overview of attention for article published in International Journal of Nanomedicine, June 2015
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Mentioned by

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2 tweeters

Citations

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27 Dimensions

Readers on

mendeley
38 Mendeley
Title
Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies
Published in
International Journal of Nanomedicine, June 2015
DOI 10.2147/ijn.s78995
Pubmed ID
Authors

Stefania Biffi, Sara Capolla, Chiara Garrovo, Sonia Zorzet, Andrea Lorenzon, Enrico Rampazzo, Ruben Spretz, Gabriele Pozzato, Luis Nunez, Paolo Macor, Claudio Tripodo

Abstract

The expectations of nanoparticle (NP)-based targeted drug delivery systems in cancer, when compared with convectional therapeutic methods, are greater efficacy and reduced drug side effects due to specific cellular-level interactions. However, there are conflicting literature reports on enhanced tumor accumulation of targeted NPs, which is essential for translating their applications as improved drug-delivery systems and contrast agents in cancer imaging. In this study, we characterized biodegradable NPs conjugated with an anti-CD20 antibody for in vivo imaging and drug delivery onto tumor cells. NPs' binding specificity mediated by anti-CD20 antibody was evaluated on MEC1 cells and chronic lymphocytic leukemia patients' cells. The whole-body distribution of untargeted NPs and anti-CD20 NPs were compared by time-domain optical imaging in a localized human/mouse model of B-cell malignancy. These studies provided evidence that NPs' functionalization by an anti-CD20 antibody improves tumor pharmacokinetic profiles in vivo after systemic administration and increases in vivo imaging of tumor mass compared to non-targeted NPs. Together, drug delivery and imaging probe represents a promising theranostics tool for targeting B-cell malignancies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 24%
Student > Master 7 18%
Student > Bachelor 6 16%
Researcher 4 11%
Student > Doctoral Student 3 8%
Other 5 13%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 29%
Biochemistry, Genetics and Molecular Biology 6 16%
Immunology and Microbiology 4 11%
Chemistry 3 8%
Materials Science 2 5%
Other 7 18%
Unknown 5 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2015.
All research outputs
#2,794,778
of 5,268,528 outputs
Outputs from International Journal of Nanomedicine
#760
of 1,386 outputs
Outputs of similar age
#102,678
of 185,423 outputs
Outputs of similar age from International Journal of Nanomedicine
#80
of 117 outputs
Altmetric has tracked 5,268,528 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,386 research outputs from this source. They receive a mean Attention Score of 1.7. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 185,423 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.