| Title |
Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies
|
|---|---|
| Published in |
International Journal of Nanomedicine, June 2015
|
| DOI | 10.2147/ijn.s78995 |
| Pubmed ID | |
| Authors |
Sara Capolla, Chiara Garrovo, Sonia Zorzet, Andrea Lorenzon, Enrico Rampazzo, Ruben Spretz, Gabriele Pozzato, Luis Núñez, Claudio Tripodo, Paolo Macor, Stefania Biffi |
| Abstract |
The expectations of nanoparticle (NP)-based targeted drug delivery systems in cancer, when compared with convectional therapeutic methods, are greater efficacy and reduced drug side effects due to specific cellular-level interactions. However, there are conflicting literature reports on enhanced tumor accumulation of targeted NPs, which is essential for translating their applications as improved drug-delivery systems and contrast agents in cancer imaging. In this study, we characterized biodegradable NPs conjugated with an anti-CD20 antibody for in vivo imaging and drug delivery onto tumor cells. NPs' binding specificity mediated by anti-CD20 antibody was evaluated on MEC1 cells and chronic lymphocytic leukemia patients' cells. The whole-body distribution of untargeted NPs and anti-CD20 NPs were compared by time-domain optical imaging in a localized human/mouse model of B-cell malignancy. These studies provided evidence that NPs' functionalization by an anti-CD20 antibody improves tumor pharmacokinetic profiles in vivo after systemic administration and increases in vivo imaging of tumor mass compared to non-targeted NPs. Together, drug delivery and imaging probe represents a promising theranostics tool for targeting B-cell malignancies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 49 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 18% |
| Student > Master | 7 | 14% |
| Student > Bachelor | 6 | 12% |
| Unspecified | 5 | 10% |
| Researcher | 5 | 10% |
| Other | 8 | 16% |
| Unknown | 10 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 22% |
| Biochemistry, Genetics and Molecular Biology | 6 | 12% |
| Unspecified | 5 | 10% |
| Immunology and Microbiology | 4 | 8% |
| Chemistry | 3 | 6% |
| Other | 10 | 20% |
| Unknown | 11 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2015.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from International Journal of Nanomedicine
#2,469
of 4,123 outputs
Outputs of similar age
#168,503
of 281,411 outputs
Outputs of similar age from International Journal of Nanomedicine
#80
of 109 outputs
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