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Mutations in presenilin 2 and its implications in Alzheimer’s disease and other dementia-associated disorders

Overview of attention for article published in Clinical Interventions in Aging, July 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
3 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
69 Dimensions

Readers on

mendeley
243 Mendeley
citeulike
1 CiteULike
Title
Mutations in presenilin 2 and its implications in Alzheimer’s disease and other dementia-associated disorders
Published in
Clinical Interventions in Aging, July 2015
DOI 10.2147/cia.s85808
Pubmed ID
Authors

Seong Soo An, Yan Cai, SangYun Kim

Abstract

Alzheimer's disease (AD) is the most common form of dementia. Mutations in the genes encoding presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein have been identified as the main genetic causes of familial AD. To date, more than 200 mutations have been described worldwide in PSEN1, which is highly homologous with PSEN2, while mutations in PSEN2 have been rarely reported. We performed a systematic review of studies describing the mutations identified in PSEN2. Most PSEN2 mutations were detected in European and in African populations. Only two were found in Korean populations. Interestingly, PSEN2 mutations appeared not only in AD patients but also in patients with other disorders, including frontotemporal dementia, dementia with Lewy bodies, breast cancer, dilated cardiomyopathy, and Parkinson's disease with dementia. Here, we have summarized the PSEN2 mutations and the potential implications of these mutations in dementia-associated disorders.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 243 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Brazil 1 <1%
Unknown 241 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 55 23%
Student > Ph. D. Student 44 18%
Student > Master 34 14%
Researcher 17 7%
Student > Doctoral Student 11 5%
Other 23 9%
Unknown 59 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 54 22%
Neuroscience 27 11%
Medicine and Dentistry 23 9%
Agricultural and Biological Sciences 22 9%
Pharmacology, Toxicology and Pharmaceutical Science 15 6%
Other 34 14%
Unknown 68 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2021.
All research outputs
#1,883,243
of 22,817,213 outputs
Outputs from Clinical Interventions in Aging
#208
of 1,839 outputs
Outputs of similar age
#25,445
of 263,426 outputs
Outputs of similar age from Clinical Interventions in Aging
#4
of 13 outputs
Altmetric has tracked 22,817,213 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,839 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.