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2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors

Overview of attention for article published in Drug Design, Development and Therapy, July 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
2 tweeters
googleplus
1 Google+ user

Readers on

mendeley
13 Mendeley
Title
2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
Published in
Drug Design, Development and Therapy, July 2015
DOI 10.2147/dddt.s86225
Pubmed ID
Authors

Lesetja Legoabe, Jacobus Petzer, Anél Petzer

Abstract

Based on a previous report that substituted 2-acetylphenols may be promising leads for the design of novel monoamine oxidase (MAO) inhibitors, a series of C5-substituted 2-acetylphenol analogs (15) and related compounds (two) were synthesized and evaluated as inhibitors of human MAO-A and MAO-B. Generally, the study compounds exhibited inhibitory activities against both MAO-A and MAO-B, with selectivity for the B isoform. Among the compounds evaluated, seven compounds exhibited IC50 values <0.01 µM for MAO-B inhibition, with the most selective compound being 17,000-fold selective for MAO-B over the MAO-A isoform. Analyses of the structure-activity relationships for MAO inhibition show that substitution on the C5 position of the 2-acetylphenol moiety is a requirement for MAO-B inhibition, and the benzyloxy substituent is particularly favorable in this regard. This study concludes that C5-substituted 2-acetylphenol analogs are potent and selective MAO-B inhibitors, appropriate for the design of therapies for neurodegenerative disorders such as Parkinson's disease.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 8%
Unknown 12 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 46%
Researcher 3 23%
Student > Ph. D. Student 1 8%
Lecturer 1 8%
Other 1 8%
Other 0 0%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 3 23%
Agricultural and Biological Sciences 2 15%
Biochemistry, Genetics and Molecular Biology 2 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 15%
Chemistry 2 15%
Other 0 0%
Unknown 2 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2017.
All research outputs
#6,433,663
of 11,477,928 outputs
Outputs from Drug Design, Development and Therapy
#337
of 1,208 outputs
Outputs of similar age
#99,659
of 231,408 outputs
Outputs of similar age from Drug Design, Development and Therapy
#38
of 167 outputs
Altmetric has tracked 11,477,928 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,208 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,408 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 167 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.