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Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles

Overview of attention for article published in International Journal of Nanomedicine, July 2015
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Mentioned by

twitter
3 tweeters

Citations

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8 Dimensions

Readers on

mendeley
19 Mendeley
Title
Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles
Published in
International Journal of Nanomedicine, July 2015
DOI 10.2147/ijn.s87816
Pubmed ID
Authors

Jin-Wook Yoo, Muhammad Naeem, Jiafu Cao, Moonjeong Choi, Wooseong Kim, Hyung Ryong Moon, Bok Luel Lee, Min-Soo Kim, Yunjin Jung

Abstract

Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive methacrylate copolymer for the treatment of colitis. The therapeutic potential of the enzyme/pH dual-sensitive nanoparticles was evaluated using a rat colitis model and compared to single pH-triggered nanoparticles. Clinical activity scores, colon/body weight ratios, myeloperoxidase activity, and proinflammatory cytokine levels were markedly decreased by dual-sensitive nanoparticles compared to single pH-triggered nanoparticles and budesonide solution. Moreover, dual-sensitive nanoparticles accumulated selectively in inflamed segments of the colon. In addition, dual-sensitive nanoparticle plasma concentrations were lower than single pH-triggered nanoparticles, and no noticeable in vitro or in vivo toxicity was observed. Our results demonstrate that enzyme/pH dual-sensitive nanoparticles are an effective and safe colon-targeted delivery system for colitis therapy.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 21%
Student > Ph. D. Student 3 16%
Researcher 3 16%
Student > Bachelor 2 11%
Lecturer > Senior Lecturer 2 11%
Other 4 21%
Unknown 1 5%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 37%
Biochemistry, Genetics and Molecular Biology 2 11%
Chemistry 2 11%
Energy 1 5%
Immunology and Microbiology 1 5%
Other 4 21%
Unknown 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2015.
All research outputs
#2,662,749
of 5,364,597 outputs
Outputs from International Journal of Nanomedicine
#525
of 1,436 outputs
Outputs of similar age
#88,029
of 174,298 outputs
Outputs of similar age from International Journal of Nanomedicine
#60
of 133 outputs
Altmetric has tracked 5,364,597 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,436 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,298 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.