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Reducible chimeric polypeptide consisting of octa-d-arginine and tetra-l-histidine peptides as an efficient gene delivery vector

Overview of attention for article published in International Journal of Nanomedicine, July 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
12 Mendeley
Title
Reducible chimeric polypeptide consisting of octa-d-arginine and tetra-l-histidine peptides as an efficient gene delivery vector
Published in
International Journal of Nanomedicine, July 2015
DOI 10.2147/ijn.s83507
Pubmed ID
Authors

Shen Gao, Xiaoyu Wang, Zongguang Tai, Jing Tian, Wei Zhang, Chong Yao, Lijuan Zhang, Yuan Gao, Quangang Zhu, Jing Gao

Abstract

Cationic oligopeptide as a nonviral gene delivery vector has aroused much research interest recently, but its further application is limited by its low transfection efficiency. In the present study, we have created a high-efficiency gene vector by using octa-d-arginine and tetra-l-histidine to form a disulfide cross-linked chimeric polypeptide and used this vector to deliver the therapeutic gene tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) to see whether the gene could be transferred and could exert antitumor effects in vitro and in vivo. The result showed that the newly designed vector was able to condense DNA into nanosized polyplexes effectively, thus facilitating its transmembrane transport, promoting its endosomal escape, and finally enabling degradation within the cell. Our study has demonstrated that this chimeric polypeptide is an effective gene carrier in cancer therapy.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 33%
Other 2 17%
Student > Master 2 17%
Student > Doctoral Student 1 8%
Researcher 1 8%
Other 0 0%
Unknown 2 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 33%
Chemistry 2 17%
Medicine and Dentistry 2 17%
Agricultural and Biological Sciences 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Other 0 0%
Unknown 2 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2015.
All research outputs
#2,238,906
of 5,397,918 outputs
Outputs from International Journal of Nanomedicine
#277
of 1,438 outputs
Outputs of similar age
#74,826
of 189,714 outputs
Outputs of similar age from International Journal of Nanomedicine
#24
of 139 outputs
Altmetric has tracked 5,397,918 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 1,438 research outputs from this source. They receive a mean Attention Score of 1.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,714 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.