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Characterization of pulmonary protein profiles in response to zinc oxide nanoparticles in mice: a 24-hour and 28-day follow-up study

Overview of attention for article published in International Journal of Nanomedicine, July 2015
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Mentioned by

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3 tweeters

Citations

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7 Dimensions

Readers on

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12 Mendeley
Title
Characterization of pulmonary protein profiles in response to zinc oxide nanoparticles in mice: a 24-hour and 28-day follow-up study
Published in
International Journal of Nanomedicine, July 2015
DOI 10.2147/ijn.s82979
Pubmed ID
Authors

Hsiao-Chi Chuang, Chih-Hong Pan, Kai-Jen Chuang, Jen-Kun Chen, Ta-Chih Hsiao, Ching-Huang Lai, Tim Jones, Kelly BéruBé, Gui-Bing Hong, Kin-Fai Ho

Abstract

Although zinc oxide nanoparticles (ZnONPs) are recognized to cause systemic disorders, little is known about the mechanisms that underlie the time-dependent differences that occur after exposure. The objective of this study was to investigate the mechanistic differences at 24 hours and 28 days after the exposure of BALB/c mice to ZnONPs via intratracheal instillation. An isobaric tag for the relative and absolute quantitation coupled with liquid chromatography/tandem mass spectrometry was used to identify the differential protein expression, biological processes, molecular functions, and pathways. A total of 18 and 14 proteins displayed significant changes in the lung tissues at 24 hours and 28 days after exposure, respectively, with the most striking changes being observed for S100-A9 protein. Metabolic processes and catalytic activity were the main biological processes and molecular functions, respectively, in the responses at the 24-hour and 28-day follow-up times. The glycolysis/gluconeogenesis pathway was continuously downregulated from 24 hours to 28 days, whereas detoxification pathways were activated at the 28-day time-point after exposure. A comprehensive understanding of the potential time-dependent effects of exposure to ZnONPs was provided, which highlights the metabolic mechanisms that may be important in the responses to ZnONP.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 3 25%
Student > Ph. D. Student 2 17%
Student > Master 2 17%
Professor 2 17%
Other 1 8%
Other 2 17%
Readers by discipline Count As %
Environmental Science 4 33%
Biochemistry, Genetics and Molecular Biology 2 17%
Medicine and Dentistry 2 17%
Immunology and Microbiology 1 8%
Psychology 1 8%
Other 1 8%
Unknown 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2015.
All research outputs
#2,683,670
of 5,407,110 outputs
Outputs from International Journal of Nanomedicine
#525
of 1,439 outputs
Outputs of similar age
#93,930
of 189,102 outputs
Outputs of similar age from International Journal of Nanomedicine
#65
of 140 outputs
Altmetric has tracked 5,407,110 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,439 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,102 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 140 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.