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Metabolomics study of the therapeutic mechanism of Schisandra chinensis lignans on aging rats induced by D-galactose

Overview of attention for article published in Clinical Interventions in Aging, May 2018
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Title
Metabolomics study of the therapeutic mechanism of <em>Schisandra chinensis</em> lignans on aging rats induced by D-galactose
Published in
Clinical Interventions in Aging, May 2018
DOI 10.2147/cia.s163275
Pubmed ID
Authors

Jinghui Sun, Shu Jing, Rui Jiang, Chunmei Wang, Chengyi Zhang, Jianguang Chen, He Li

Abstract

The aim of this study was to evaluate the antiaging effect of Schisandra chinensis lignans (SCL) by analyzing the characteristics in the serum of d-galactose (d-gal)-induced rats. Forty male Wistar rats were randomly divided into control group, d-gal model group, low-dose SCL group (50 mg/kg/d), medium-dose SCL group (100 mg/kg/d), and high-dose SCL group (200 mg/kg/d). A serum metabolomics analysis method based on rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry was carried out to study the characteristics of d-gal-induced aging rats and evaluate the antiaging effects of SCL, and multivariate statistical analysis was performed for pattern recognition and characteristic metabolites identification. The relative levels of p19, p53, and p21 genes in the brain tissue were measured by quantitative real-time polymerase chain reaction for investigating the underlying mechanism. Metabolomics analysis showed that 15 biomarkers were identified and 13 of them recovered to the normal levels after the administration of SCL. Based on the pathway analysis, the antiaging mechanisms of SCL might be involved in the following metabolic pathways: energy, amino acid, lipid, and phospholipid metabolism. Furthermore, SCL significantly inhibited the mRNA expression level of p19, p53, and p21 in the brain of aging rats induced by d-gal. These results suggest that SCL can delay rat aging induced by d-gal through multiple pathways.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 2 18%
Student > Master 2 18%
Student > Ph. D. Student 1 9%
Student > Bachelor 1 9%
Student > Doctoral Student 1 9%
Other 2 18%
Unknown 2 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 18%
Unspecified 1 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Psychology 1 9%
Medicine and Dentistry 1 9%
Other 1 9%
Unknown 4 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2018.
All research outputs
#12,436,543
of 14,064,191 outputs
Outputs from Clinical Interventions in Aging
#1,320
of 1,432 outputs
Outputs of similar age
#237,917
of 275,980 outputs
Outputs of similar age from Clinical Interventions in Aging
#27
of 29 outputs
Altmetric has tracked 14,064,191 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,432 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,980 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.