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Meta-analysis of segmentectomy versus wedge resection in stage IA non-small-cell lung cancer

Overview of attention for article published in OncoTargets and therapy, June 2018
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Mentioned by

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1 Redditor

Citations

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Readers on

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9 Mendeley
Title
Meta-analysis of segmentectomy versus wedge resection in stage IA non-small-cell lung cancer
Published in
OncoTargets and therapy, June 2018
DOI 10.2147/ott.s161367
Pubmed ID
Authors

Wenfei Xue, Guochen Duan, Xiaopeng Zhang, Hua Zhang, Qingtao Zhao, Zhifei Xin

Abstract

Although limited resection was once considered the surgical treatment for patients with Phase IA non-small-cell lung cancer (NSCLC), there has been an ongoing controversial surgical indication for wedge resection and segmentectomy in recent years. The objective of this study was to compare overall survival (OS) and disease-free survival (DFS) of segmentectomy and wedge resection for early stage NSCLC, using a meta-analysis. Systematic research was conducted using four online databases to search for studies published before 2017. The DFS and OS for early stage NSCLC after segmentectomy and wedge resection were compared. The studies were selected according to rigorous predefined inclusion criteria, and meta-analyzed using the log (hazard ratio; ln[HR]) and its standard error (SE) calculations. Included in this meta-analysis were nine studies, published from 2006 to 2017, with a total of 7,272 patients. Survival outcome of segmentectomy was comparable to wedge resections for stage IA lung cancer because of OS (similar hazard ratio [HR]: 0.93, 95% confidence interval [CI]: 0.83-1.05, P=0.26) and DFS (similar HR: 0.81, 95% CI: 0.60-1.09, P=0.17). Nevertheless, for stage IA NSCLC with tumor size ≤2 cm, segmentectomy was superior to wedge resection (combined HR: 0.82, 95% CI: 0.70-0.97, P=0.02). However, there were no significant differences in OS rates, 1.07 (95% CI: 0.78-1.46, P=0.68), between segmentectomy and wedge resection for IA NSCLC with a tumor size of ≤1 cm. This study concluded that segmentectomy could achieve better OS than wedge resection for stage IA NSCLC with a tumor size of ≤2 cm. However, surgeons could conduct segmentectomy and wedge resection for NSCLC ≤1 cm according to patient profile and the location of tumor. These results should be confirmed by further randomized clinical trials.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 22%
Student > Bachelor 2 22%
Student > Doctoral Student 1 11%
Lecturer 1 11%
Researcher 1 11%
Other 2 22%
Readers by discipline Count As %
Medicine and Dentistry 6 67%
Social Sciences 1 11%
Biochemistry, Genetics and Molecular Biology 1 11%
Unknown 1 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2018.
All research outputs
#11,589,754
of 13,044,924 outputs
Outputs from OncoTargets and therapy
#1,192
of 1,697 outputs
Outputs of similar age
#234,721
of 270,623 outputs
Outputs of similar age from OncoTargets and therapy
#44
of 48 outputs
Altmetric has tracked 13,044,924 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,697 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,623 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.