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Periostin overexpression is associated with worse prognosis in nasopharyngeal carcinoma from endemic area: a cohort study

Overview of attention for article published in OncoTargets and therapy, May 2018
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Title
Periostin overexpression is associated with worse prognosis in nasopharyngeal carcinoma from endemic area: a cohort study
Published in
OncoTargets and therapy, May 2018
DOI 10.2147/ott.s163626
Pubmed ID
Authors

Yu-Ching Wei, Sheau-Fang Yang, Shih-Lun Chang, Tzu-Ju Chen, Sung-Wei Lee, Hung-Sung Chen, Li-Ching Lin, Chien-Feng Li

Abstract

Nasopharyngeal carcinoma (NPC) is a heterogeneous disease. We searched for genes that function in cell adhesion in GSE12452, a published transcriptomic database. We found that POSTN, which encodes periostin (POSTN), was significantly upregulated in NPC tumorigenesis. Herein, we sought to analyze the expression of POSTN and its prognostic significances in patients with NPC. In this single-institution retrospective study, we determined and analyzed POSTN expression by immunohistochemistry and H-score method, respectively, in 124 patients with NPC. The results indicated that POSTN expression was correlated with the clinicopathologic features, disease-specific survival (DSS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS) of NPC. We performed univariate and multivariate analyses to determinate the statistical significance. High POSTN expression was significantly associated with lymph node metastasis (p=0.004) and advanced American Joint Committee on Cancer (AJCC) stage (p=0.006). In univariate analysis, high POSTN expression served as a significant prognostic factor for worse DSS (p=0.0002), DMFS (p=0.0138), and LRFS (p=0.0028). In multivariate Cox regression analyses, which was adjusted for AJCC stages, POSTN expression was independently associated with cancer-related death (HR: 2.311; 95% CI: 1.327-4.027; p=0.003) and local tumor recurrence (HR: 3.187; 95% CI: 1.108-4.408; p=0.024). High POSTN expression is associated with tumor aggressiveness and worse clinical outcomes in NPC, indicating that it may be a potential prognostic biomarker and a therapeutic target.

Twitter Demographics

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 1 50%
Unknown 1 50%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 50%
Unknown 1 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2018.
All research outputs
#11,588,539
of 13,043,953 outputs
Outputs from OncoTargets and therapy
#1,192
of 1,697 outputs
Outputs of similar age
#234,579
of 270,453 outputs
Outputs of similar age from OncoTargets and therapy
#43
of 49 outputs
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