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Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

twitter
1 tweeter
googleplus
1 Google+ user

Citations

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56 Dimensions

Readers on

mendeley
32 Mendeley
Title
Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction
Published in
International Journal of Chronic Obstructive Pulmonary Disease, August 2015
DOI 10.2147/copd.s81032
Pubmed ID
Authors

Malik Mahmood, Sukhwinder Singh Sohal, Shakti Dhar Shukla, Ashutosh Hardikar, Wan Danial Noor, Hans Konrad Muller, Darryl Knight, Eugene Haydn Walters, Chris Ward

Abstract

Small airway fibrosis is the main contributor in airflow obstruction in chronic obstructive pulmonary disease. Epithelial mesenchymal transition (EMT) has been implicated in this process, and in large airways, is associated with angiogenesis, ie, Type-3, which is classically promalignant. In this study we have investigated whether EMT biomarkers are expressed in small airways compared to large airways in subjects with chronic airflow limitation (CAL) and what type of EMT is present on the basis of vascularity. We evaluated epithelial activation, reticular basement membrane fragmentation (core structural EMT marker) and EMT-related mesenchymal biomarkers in small and large airways from resected lung tissue from 18 lung cancer patients with CAL and 9 normal controls. Tissues were immunostained for epidermal growth factor receptor (EGFR; epithelial activation marker), vimentin (mesenchymal marker), and S100A4 (fibroblast epitope). Type-IV collagen was stained to demonstrate vessels. There was increased expression of EMT-related markers in CAL small airways compared to controls: EGFR (P<0.001), vimentin (P<0.001), S100A4 (P<0.001), and fragmentation (P<0.001), but this was less than that in large airways. Notably, there was no hypervascularity in small airway reticular basement membrane as in large airways. Epithelial activation and S100A4 expression were related to airflow obstruction. EMT is active in small airways, but less so than in large airways in CAL, and may be relevant to the key pathologies of chronic obstructive pulmonary disease, small airway fibrosis, and airway cancers.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 4 13%
Researcher 4 13%
Student > Master 4 13%
Student > Ph. D. Student 4 13%
Other 3 9%
Other 7 22%
Unknown 6 19%
Readers by discipline Count As %
Medicine and Dentistry 11 34%
Agricultural and Biological Sciences 4 13%
Biochemistry, Genetics and Molecular Biology 3 9%
Unspecified 1 3%
Nursing and Health Professions 1 3%
Other 5 16%
Unknown 7 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2015.
All research outputs
#2,517,097
of 5,450,695 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#301
of 699 outputs
Outputs of similar age
#85,562
of 190,007 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#37
of 92 outputs
Altmetric has tracked 5,450,695 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 699 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,007 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.