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Thiazolidinediones are associated with a reduced risk of COPD exacerbations

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, August 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

policy
1 policy source
twitter
2 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
22 Dimensions

Readers on

mendeley
34 Mendeley
Title
Thiazolidinediones are associated with a reduced risk of COPD exacerbations
Published in
International Journal of Chronic Obstructive Pulmonary Disease, August 2015
DOI 10.2147/copd.s82643
Pubmed ID
Authors

Seppo Rinne, Laura Feemster, Bridget Collins, Chuan-Fen Liu, Christopher Bryson, Thomas O'Riordan, David Au

Abstract

Thiazolidinediones (TZDs) are oral antihyperglycemic medications that are selective agonists to peroxisome proliferator-activated receptor gamma and have been shown to have potent anti-inflammatory effects in the lung. The purpose of this study was to assess whether exposure to TZDs is associated with a decreased risk of chronic obstructive pulmonary disease (COPD) exacerbation. A cohort study was performed by collecting data on all US veterans with diabetes and COPD who were prescribed oral antihyperglycemic medications during from period of October 1, 2005 to September 30, 2007. Patients who had two or more prescriptions for TZDs were compared with patients who had two or more prescriptions for an alternative oral anti-hyperglycemic medication. Multivariable negative binomial regression was performed with adjustment for potential confounding factors. The primary outcome was COPD exacerbations, including both inpatient and outpatient exacerbations. We identified 7,887 veterans who were exposed to TZD and 42,347 veterans who were exposed to non-TZD oral diabetes medications. COPD exacerbations occurred in 1,258 (16%) of the TZD group and 7,789 (18%) of the non-TZD group. In multivariable negative binomial regression, there was a significant reduction in the expected number of COPD exacerbations among patients who were exposed to TZDs with an incidence rate ratio of 0.86 (95% CI 0.81-0.92). Exposure to TZDs was associated with a small but significant reduction in risk for COPD exacerbation among diabetic patients with COPD.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 26%
Researcher 5 15%
Student > Bachelor 3 9%
Other 3 9%
Student > Ph. D. Student 2 6%
Other 5 15%
Unknown 7 21%
Readers by discipline Count As %
Medicine and Dentistry 11 32%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Nursing and Health Professions 2 6%
Computer Science 2 6%
Immunology and Microbiology 1 3%
Other 5 15%
Unknown 10 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2018.
All research outputs
#4,586,726
of 17,356,510 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#533
of 1,971 outputs
Outputs of similar age
#61,348
of 241,351 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#22
of 96 outputs
Altmetric has tracked 17,356,510 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,971 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,351 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.