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The structural equation analysis of childhood abuse, adult stressful life events, and temperaments in major depressive disorders and their influence on refractoriness

Overview of attention for article published in Neuropsychiatric Disease and Treatment, August 2015
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2 tweeters

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69 Mendeley
Title
The structural equation analysis of childhood abuse, adult stressful life events, and temperaments in major depressive disorders and their influence on refractoriness
Published in
Neuropsychiatric Disease and Treatment, August 2015
DOI 10.2147/ndt.s82236
Pubmed ID
Authors

Hiroyuki Toda, Tomoya Tsunoda, Masaaki Tanichi, Teppei Tanaka, Naoki Hashimoto, Yasuya Nakato, Shin Nakagawa, Yuji Kitaichi, Nobuyuki Mitsui, Shuken Boku, Hajime Tanabe, Masashi Nibuya, Aihide Yoshino, Ichiro Kusumi, Yukiei Nakai, Takeshi Inoue

Abstract

Previous studies have shown the interaction between heredity and childhood stress or life events on the pathogenesis of a major depressive disorder (MDD). In this study, we tested our hypothesis that childhood abuse, affective temperaments, and adult stressful life events interact and influence the diagnosis of MDD. A total of 170 healthy controls and 98 MDD patients were studied using the following self-administered questionnaire surveys: the Patient Health Questionnaire-9 (PHQ-9), the Life Experiences Survey, the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire, and the Child Abuse and Trauma Scale (CATS). The data were analyzed with univariate analysis, multivariable analysis, and structural equation modeling. The neglect scores of the CATS indirectly predicted the diagnosis of MDD through cyclothymic and anxious temperament scores of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire in the structural equation modeling. Two temperaments - cyclothymic and anxious - directly predicted the diagnosis of MDD. The validity of this result was supported by the results of the stepwise multivariate logistic regression analysis as follows: three factors - neglect, cyclothymic, and anxious temperaments - were significant predictors of MDD. Neglect and the total CATS scores were also predictors of remission vs treatment-resistance in MDD patients independently of depressive symptoms. The sample size was small for the comparison between the remission and treatment-resistant groups in MDD patients in multivariable analysis. This study suggests that childhood abuse, especially neglect, indirectly predicted the diagnosis of MDD through increased affective temperaments. The important role as a mediator of affective temperaments in the effect of childhood abuse on MDD was suggested.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
Mexico 1 1%
Unknown 67 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 14%
Researcher 10 14%
Student > Doctoral Student 6 9%
Student > Bachelor 6 9%
Professor 5 7%
Other 14 20%
Unknown 18 26%
Readers by discipline Count As %
Psychology 19 28%
Medicine and Dentistry 15 22%
Neuroscience 5 7%
Social Sciences 4 6%
Agricultural and Biological Sciences 3 4%
Other 2 3%
Unknown 21 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2015.
All research outputs
#9,126,279
of 14,535,828 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,469
of 2,442 outputs
Outputs of similar age
#125,329
of 236,117 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#91
of 103 outputs
Altmetric has tracked 14,535,828 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,442 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,117 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.