| Title |
The structural equation analysis of childhood abuse, adult stressful life events, and temperaments in major depressive disorders and their influence on refractoriness
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, August 2015
|
| DOI | 10.2147/ndt.s82236 |
| Pubmed ID | |
| Authors |
Hiroyuki Toda, Takeshi Inoue, Tomoya Tsunoda, Yukiei Nakai, Masaaki Tanichi, Teppei Tanaka, Naoki Hashimoto, Yasuya Nakato, Shin Nakagawa, Yuji Kitaichi, Nobuyuki Mitsui, Shuken Boku, Hajime Tanabe, Masashi Nibuya, Aihide Yoshino, Ichiro Kusumi |
| Abstract |
Previous studies have shown the interaction between heredity and childhood stress or life events on the pathogenesis of a major depressive disorder (MDD). In this study, we tested our hypothesis that childhood abuse, affective temperaments, and adult stressful life events interact and influence the diagnosis of MDD. A total of 170 healthy controls and 98 MDD patients were studied using the following self-administered questionnaire surveys: the Patient Health Questionnaire-9 (PHQ-9), the Life Experiences Survey, the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire, and the Child Abuse and Trauma Scale (CATS). The data were analyzed with univariate analysis, multivariable analysis, and structural equation modeling. The neglect scores of the CATS indirectly predicted the diagnosis of MDD through cyclothymic and anxious temperament scores of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire in the structural equation modeling. Two temperaments - cyclothymic and anxious - directly predicted the diagnosis of MDD. The validity of this result was supported by the results of the stepwise multivariate logistic regression analysis as follows: three factors - neglect, cyclothymic, and anxious temperaments - were significant predictors of MDD. Neglect and the total CATS scores were also predictors of remission vs treatment-resistance in MDD patients independently of depressive symptoms. The sample size was small for the comparison between the remission and treatment-resistant groups in MDD patients in multivariable analysis. This study suggests that childhood abuse, especially neglect, indirectly predicted the diagnosis of MDD through increased affective temperaments. The important role as a mediator of affective temperaments in the effect of childhood abuse on MDD was suggested. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Mexico | 1 | 1% |
| Unknown | 81 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 14% |
| Researcher | 11 | 13% |
| Student > Bachelor | 9 | 11% |
| Student > Doctoral Student | 6 | 7% |
| Professor | 5 | 6% |
| Other | 15 | 18% |
| Unknown | 25 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 21 | 25% |
| Medicine and Dentistry | 15 | 18% |
| Neuroscience | 6 | 7% |
| Social Sciences | 5 | 6% |
| Agricultural and Biological Sciences | 3 | 4% |
| Other | 4 | 5% |
| Unknown | 29 | 35% |
Attention Score in Context
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#17,285,668
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Outputs from Neuropsychiatric Disease and Treatment
#1,901
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#165,173
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Outputs of similar age from Neuropsychiatric Disease and Treatment
#80
of 92 outputs
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