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Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

Overview of attention for article published in International Journal of Nanomedicine, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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2 tweeters
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1 Google+ user

Citations

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24 Dimensions

Readers on

mendeley
54 Mendeley
Title
Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint
Published in
International Journal of Nanomedicine, August 2015
DOI 10.2147/ijn.s88363
Pubmed ID
Authors

Myung Joo Kang, Sung Rae Kim, Myoung Jin Ho, Eugene Lee, Joon Woo Lee, Young Wook Choi

Abstract

Positively surface-charged poly(lactide-co-glycolide) (PLGA)/Eudragit RL nanoparticles (NPs) were designed to increase retention time and sustain release profile in joints after intra-articular injection, by forming micrometer-sized electrostatic aggregates with hyaluronic acid, an endogenous anionic polysaccharide found in high amounts in synovial fluid. The cationic NPs consisting of PLGA, Eudragit RL, and polyvinyl alcohol were fabricated by solvent evaporation technique. The NPs were 170.1 nm in size, with a zeta potential of 21.3 mV in phosphate-buffered saline. Hyperspectral imaging (CytoViva(®)) revealed the formation of the micrometer-sized filamentous aggregates upon admixing, due to electrostatic interaction between NPs and the polysaccharides. NPs loaded with a fluorescent probe (1,1'-dioctadecyl-3,3,3',3' tetramethylindotricarbocyanine iodide, DiR) displayed a significantly improved retention time in the knee joint, with over 50% preservation of the fluorescent signal 28 days after injection. When DiR solution was injected intra-articularly, the fluorescence levels rapidly decreased to 30% of the initial concentration within 3 days in mice. From these findings, we suggest that PLGA-based cationic NPs could be a promising tool for prolonged delivery of therapeutic agents in joints selectively.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 37%
Student > Bachelor 8 15%
Student > Master 7 13%
Researcher 6 11%
Student > Doctoral Student 4 7%
Other 3 6%
Unknown 6 11%
Readers by discipline Count As %
Engineering 13 24%
Pharmacology, Toxicology and Pharmaceutical Science 10 19%
Medicine and Dentistry 7 13%
Agricultural and Biological Sciences 4 7%
Materials Science 4 7%
Other 7 13%
Unknown 9 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2015.
All research outputs
#2,294,927
of 5,526,402 outputs
Outputs from International Journal of Nanomedicine
#287
of 1,466 outputs
Outputs of similar age
#75,501
of 194,206 outputs
Outputs of similar age from International Journal of Nanomedicine
#31
of 155 outputs
Altmetric has tracked 5,526,402 research outputs across all sources so far. This one has received more attention than most of these and is in the 56th percentile.
So far Altmetric has tracked 1,466 research outputs from this source. They receive a mean Attention Score of 1.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,206 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 155 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.