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Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery

Overview of attention for article published in International Journal of Nanomedicine, July 2015
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3 Facebook pages

Citations

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33 Dimensions

Readers on

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47 Mendeley
Title
Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery
Published in
International Journal of Nanomedicine, July 2015
DOI 10.2147/ijn.s85999
Pubmed ID
Authors

Ai-Zheng Chen, Lin-qing Chen, Shi-bin Wang, Ya-qiong Wang, Jun-zhe Zha

Abstract

A synergistic approach by the combination of magnetic nanoparticles with an alternating magnetic field for transdermal drug delivery was investigated. Methotrexate-loaded silk fibroin magnetic nanoparticles were prepared using suspension-enhanced dispersion by supercritical CO2. The physiochemical properties of the magnetic nanoparticles were characterized. In vitro studies on drug permeation across skin were performed under different magnetic fields in comparison with passive diffusion. The permeation flux enhancement factor was found to increase under a stationary magnetic field, while an alternating magnetic field enhanced drug permeation more effectively; the combination of stationary and alternating magnetic fields, which has a massage-like effect on the skin, achieved the best result. The mechanistic studies using attenuated total reflection Fourier-transform infrared spectroscopy demonstrate that an alternating magnetic field can change the ordered structure of the stratum corneum lipid bilayers from the gel to the lipid-crystalline state, which can increase the fluidity of the stratum corneum lipids, thus enhancing skin penetration. Compared with the other groups, the fluorescence signal with a bigger area detected in deeper regions of the skin also reveals that the simulated massage could enhance the drug permeation across the skin by increasing the follicular transport. The combination of magnetic nanoparticles with stationary/alternating magnetic fields has potential for effective massage-like transdermal drug delivery.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 28%
Researcher 7 15%
Student > Bachelor 7 15%
Student > Master 4 9%
Professor 2 4%
Other 5 11%
Unknown 9 19%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 8 17%
Agricultural and Biological Sciences 8 17%
Engineering 6 13%
Chemical Engineering 4 9%
Biochemistry, Genetics and Molecular Biology 3 6%
Other 8 17%
Unknown 10 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2016.
All research outputs
#12,307,127
of 16,138,771 outputs
Outputs from International Journal of Nanomedicine
#2,092
of 2,993 outputs
Outputs of similar age
#154,123
of 241,233 outputs
Outputs of similar age from International Journal of Nanomedicine
#129
of 155 outputs
Altmetric has tracked 16,138,771 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,993 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,233 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 155 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.