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20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway

Overview of attention for article published in Drug Design, Development and Therapy, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

twitter
3 tweeters

Citations

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33 Dimensions

Readers on

mendeley
13 Mendeley
Title
20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
Published in
Drug Design, Development and Therapy, August 2015
DOI 10.2147/dddt.s84527
Pubmed ID
Authors

Ping Dong, Fei Zhang, Xiangsong Wu, Yunping Hu, Yang Cao, Xu’an Wang, Shanshan Xiang, Maolan Li, Lin Jiang, Zhujun Tan, Wei Lu, Hao Weng, Yijun Sun, Wei Gong, Xuefeng Wang, Yong Zhang, Weibin Shi, Jun Gu, Yingbin Liu, Huaifeng Li

Abstract

Gallbladder cancer (GBC), the most frequent malignancy of the biliary tract, is associated with high mortality and extremely poor prognosis. 20(S)-ginsenoside Rg3 (20(S)-Rg3) is a steroidal saponin with high pharmacological activity. However, the anticancer effect of 20(S)-Rg3 in human GBC has not yet been determined. In this study, we primarily found that 20(S)-Rg3 exposure suppressed the survival of both NOZ and GBC-SD cell lines in a concentration-dependent manner. Moreover, induction of cellular senescence and G0/G1 arrest by 20(S)-Rg3 were accompanied by a large accumulation of p53 and p21 as a result of murine double minute 2 (MDM2) inhibition. 20(S)-Rg3 also caused a remarkable increase in apoptosis via the activation of the mitochondrial-mediated intrinsic caspase pathway. Furthermore, intraperitoneal injection of 20(S)-Rg3 (20 or 40 mg/kg) for 3 weeks markedly inhibited the growth of xenografts in nude mice. Our results demonstrated that 20(S)-Rg3 potently inhibited growth and survival of GBC cells both in vitro and in vivo. 20(S)-Rg3 attenuated GBC growth probably via activation of the p53 pathway, and subsequent induction of cellular senescence and mitochondrial-dependent apoptosis. Therefore, 20(S)-Rg3 may be a potential chemotherapeutic agent for GBC therapy.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 38%
Student > Ph. D. Student 3 23%
Student > Bachelor 2 15%
Other 1 8%
Student > Doctoral Student 1 8%
Other 1 8%
Readers by discipline Count As %
Unspecified 5 38%
Pharmacology, Toxicology and Pharmaceutical Science 2 15%
Agricultural and Biological Sciences 2 15%
Medicine and Dentistry 2 15%
Immunology and Microbiology 1 8%
Other 1 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2016.
All research outputs
#3,538,927
of 7,851,688 outputs
Outputs from Drug Design, Development and Therapy
#244
of 1,008 outputs
Outputs of similar age
#93,473
of 229,987 outputs
Outputs of similar age from Drug Design, Development and Therapy
#28
of 147 outputs
Altmetric has tracked 7,851,688 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 1,008 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,987 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.