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Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy

Overview of attention for article published in International Journal of Nanomedicine, September 2015
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Mentioned by

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1 tweeter
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1 Google+ user

Citations

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Readers on

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26 Mendeley
Title
Multi-small molecule conjugations as new targeted delivery carriers for tumor therapy
Published in
International Journal of Nanomedicine, September 2015
DOI 10.2147/ijn.s85402
Pubmed ID
Authors

Lingling Shan, Ming Liu, Chao Wu, Liang Zhao, Siwen Li, Lisheng Xu, Wengen Cao, Guizhen Gao, Yueqing Gu

Abstract

In response to the challenges of cancer chemotherapeutics, including poor physicochemical properties, low tumor targeting ability, and harmful side effects, we developed a new tumor-targeted multi-small molecule drug delivery platform. Using paclitaxel (PTX) as a model therapeutic, we prepared two prodrugs, ie, folic acid-fluorescein-5(6)-isothiocyanate-arginine-paclitaxel (FA-FITC-Arg-PTX) and folic acid-5-aminofluorescein-glutamic-paclitaxel (FA-5AF-Glu-PTX), composed of folic acid (FA, target), amino acids (Arg or Glu, linker), and fluorescent dye (fluorescein in vitro or near-infrared fluorescent dye in vivo) in order to better understand the mechanism of PTX prodrug targeting. In vitro and acute toxicity studies demonstrated the low toxicity of the prodrug formulations compared with the free drug. In vitro and in vivo studies indicated that folate receptor-mediated uptake of PTX-conjugated multi-small molecule carriers induced high antitumor activity. Notably, compared with free PTX and with PTX-loaded macromolecular carriers from our previous study, this multi-small molecule-conjugated strategy improved the water solubility, loading rate, targeting ability, antitumor activity, and toxicity profile of PTX. These results support the use of multi-small molecules as tumor-targeting drug delivery systems.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 27%
Student > Master 6 23%
Student > Ph. D. Student 3 12%
Other 2 8%
Researcher 2 8%
Other 2 8%
Unknown 4 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 15%
Chemistry 4 15%
Medicine and Dentistry 4 15%
Biochemistry, Genetics and Molecular Biology 3 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Other 4 15%
Unknown 5 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2015.
All research outputs
#2,802,329
of 6,361,288 outputs
Outputs from International Journal of Nanomedicine
#583
of 1,530 outputs
Outputs of similar age
#96,070
of 195,350 outputs
Outputs of similar age from International Journal of Nanomedicine
#80
of 146 outputs
Altmetric has tracked 6,361,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 1,530 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,350 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.