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Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjugated gold nanoparticles

Overview of attention for article published in International Journal of Nanomedicine, September 2015
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Mentioned by

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3 tweeters

Citations

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8 Dimensions

Readers on

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13 Mendeley
Title
Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjugated gold nanoparticles
Published in
International Journal of Nanomedicine, September 2015
DOI 10.2147/ijn.s87174
Pubmed ID
Authors

Mathias Gehrmann, Melanie Kimm, Stefan Stangl, Thomas Schmid, Peter Noël, Ernst Rummeny, Gabriele Multhoff

Abstract

Real-time imaging of small tumors is still one of the challenges in cancer diagnosis, prognosis, and monitoring of clinical outcome. Targeting novel biomarkers that are selectively expressed on a large variety of different tumors but not normal cells has the potential to improve the imaging capacity of existing methods such as computed tomography. Herein, we present a novel technique using cmHsp70.1 monoclonal antibody-conjugated spherical gold nanoparticles for quantification of the targeted uptake of gold nanoparticles into membrane Hsp70-positive tumor cells. Upon binding, cmHsp70.1-conjugated gold nanoparticles but not nanoparticles coupled to an isotype-matched IgG1 antibody or empty nanoparticles are rapidly taken up by highly malignant Hsp70 membrane-positive mouse tumor cells. After 24 hours, the cmHsp70.1-conjugated gold nanoparticles are found to be enriched in the perinuclear region. Specificity for membrane Hsp70 was shown by using an Hsp70 knockout tumor cell system. Toxic side effects of the cmHsp70.1-conjugated nanoparticles are not observed at a concentration of 1-10 µg/mL. Experiments are ongoing to evaluate whether cmHsp70.1 antibody-conjugated gold nanoparticles are suitable for the detection of membrane-Hsp70-positive tumors in vivo.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 23%
Student > Ph. D. Student 3 23%
Student > Doctoral Student 2 15%
Researcher 1 8%
Other 1 8%
Other 3 23%
Readers by discipline Count As %
Unspecified 5 38%
Medicine and Dentistry 3 23%
Chemistry 1 8%
Physics and Astronomy 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Other 2 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2015.
All research outputs
#2,782,788
of 6,316,402 outputs
Outputs from International Journal of Nanomedicine
#573
of 1,513 outputs
Outputs of similar age
#95,720
of 194,912 outputs
Outputs of similar age from International Journal of Nanomedicine
#81
of 147 outputs
Altmetric has tracked 6,316,402 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 1,513 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,912 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.