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Over-expression of nuclear factor-κB family genes and inflammatory molecules is related to chronic obstructive pulmonary disease

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, July 2018
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Title
Over-expression of nuclear factor-κB family genes and inflammatory molecules is related to chronic obstructive pulmonary disease
Published in
International Journal of Chronic Obstructive Pulmonary Disease, July 2018
DOI 10.2147/copd.s164151
Pubmed ID
Authors

Liting Zhou, Ying Liu, Xin Chen, Shuyue Wang, Hongbo Liu, Tianrong Zhang, Yuezhu Zhang, Qi Xu, Xu Han, Yaming Zhao, Xinyue Song, Lin Ye

Abstract

Nuclear factor-κB (NF-κB) signaling plays essential roles in inflammatory responses. However, whether the expression levels of NF-κB family genes affect inflammatory responses is unclear. Moreover, little is known regarding the association between NF-κB family genes expression and the pathogenesis of chronic obstructive pulmonary disease (COPD). The present study was undertaken to assess the relationship between the expression levels of NF-κB family genes mRNA and of inflammatory markers relevant to COPD pathogenesis. A total of 186 unrelated patients with acute exacerbations of COPD and 180 healthy controls were recruited. Total RNA was extracted from the peripheral fasting blood of each subject using trizol reagent. The mRNA levels of NF-κB family genes (NF-κB1, NF-κB2 and c-REL) were measured by real-time quantitative polymerase chain reaction. The serum levels of cyclooxygenase-2 (COX-2), C-reactive protein, interleukin (IL)-1β, IL-6, IL-8, IL-12 and tumor necrosis factor-α were measured with enzyme-linked immunosorbent assay kits. The relative mRNA levels of the NF-κB family genes and the levels of inflammatory molecules were significantly higher in the COPD group than in the control group after adjustment for smoking. The IL-1β, IL-8 and COX-2 levels were significantly lower in the NF-κB2 under-expression subgroup as compared to the NF-κB2 over-expression subgroup. The COX-2 level was significantly lower (P < 0.05) in the c-REL under-expression subgroup as compared to the c-REL over-expression subgroup. NF-κB2 over-expression was associated with IL-1β, IL-8 and COX-2 levels, whereas c-REL overexpression was associated with COX-2 level. Over-expression of both NF-κB2 and c-REL was found to be related to COPD.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 42%
Researcher 2 17%
Lecturer 2 17%
Student > Postgraduate 1 8%
Unknown 2 17%
Readers by discipline Count As %
Medicine and Dentistry 4 33%
Nursing and Health Professions 2 17%
Unspecified 1 8%
Immunology and Microbiology 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Other 1 8%
Unknown 2 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2018.
All research outputs
#10,528,330
of 13,216,344 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,299
of 1,610 outputs
Outputs of similar age
#198,875
of 266,567 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#46
of 54 outputs
Altmetric has tracked 13,216,344 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,610 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,567 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.