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Targeting interleukin-6 for noninfectious uveitis

Overview of attention for article published in Clinical Ophthalmology, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

twitter
3 tweeters
patent
2 patents

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
50 Mendeley

What is this page?

Summary Twitter Patents Dimensions citations
Title
Targeting interleukin-6 for noninfectious uveitis
Published in
Clinical Ophthalmology, September 2015
DOI 10.2147/opth.s68595
Pubmed ID
26392750
Authors

Phoebe Lin

Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine implicated in the pathogenesis of many immune-mediated disorders including several types of non-infectious uveitis. These uveitic conditions include Vogt-Koyanagi-Harada syndrome, uveitis associated with Behçet disease, and sarcoidosis. This review summarizes the role of IL-6 in immunity, highlighting its effect on Th17, Th1, and plasmablast differentiation. It reviews the downstream mediators activated in the process of IL-6 binding to its receptor complex. This review also summarizes the biologics targeting either IL-6 or the IL-6 receptor, including tocilizumab, sarilumab, sirukumab, olokizumab, clazakizumab, and siltuximab. The target, dosage, potential side effects, and potential uses of these biologics are summarized in this article based on the existing literature. In summary, anti-IL-6 therapy for non-infectious uveitis shows promise in terms of efficacy and side effect profile.

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Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 16%
Other 7 14%
Student > Ph. D. Student 7 14%
Student > Bachelor 4 8%
Student > Postgraduate 4 8%
Other 9 18%
Unknown 11 22%
Readers by discipline Count As %
Medicine and Dentistry 25 50%
Biochemistry, Genetics and Molecular Biology 4 8%
Agricultural and Biological Sciences 3 6%
Immunology and Microbiology 2 4%
Economics, Econometrics and Finance 2 4%
Other 1 2%
Unknown 13 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2022.
All research outputs
#4,039,994
of 22,908,162 outputs
Outputs from Clinical Ophthalmology
#307
of 3,200 outputs
Outputs of similar age
#51,850
of 266,948 outputs
Outputs of similar age from Clinical Ophthalmology
#3
of 84 outputs
Altmetric has tracked 22,908,162 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,200 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,948 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.

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