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Hyperhomocysteinemia is an independent predictor of long-term clinical outcomes in Chinese octogenarians with acute coronary syndrome

Overview of attention for article published in Clinical Interventions in Aging, January 2015
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Mentioned by

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3 tweeters

Citations

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18 Dimensions

Readers on

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26 Mendeley
Title
Hyperhomocysteinemia is an independent predictor of long-term clinical outcomes in Chinese octogenarians with acute coronary syndrome
Published in
Clinical Interventions in Aging, January 2015
DOI 10.2147/cia.s91652
Pubmed ID
Authors

Zhenhong Fu, Yundai Chen, Xia Yang, Xue Hao, Wei Dong, Lian Chen, Geng Qian, Mingzhi Shen, Jun Guo

Abstract

To evaluate the prognostic value of homocysteine (Hcy) in Chinese acute coronary syndrome (ACS) octogenarians. The study cohort comprised 660 consecutive ACS octogenarians who underwent coronary angiography. We classified the patients into three groups according to Hcy tertiles. Kaplan-Meier method was performed for survival and major adverse cardiac events (MACE) rates. Multivariate Cox regression was performed to identify mortality predictors. Receiver operating characteristic curve analysis was performed to predict the cutoff value of Hcy for all-cause mortality. The follow-up period was 28 (inter-quartile range: 16-38) months. Diastolic blood pressure, ratios of male, renal failure and old myocardial infarction in high plasma level Hcy (H-Hcy) group were higher than those in low (L-Hcy) and middle (M-Hcy) plasma level of Hcy groups (P<0.05). The Hcy level was positively correlated with uric acid level (r=0.211, P=0.001) and Cystatin C (Cys C) level (r=0.212, P=0.001) and negatively correlated with estimated glomerular filtration rate (r=-0.148, P=0.018). For the long-term outcomes, the cumulative survival rate of H-Hcy group was significantly lower than that of L-Hcy and M-Hcy groups (P=0.006). All-cause mortality and MACE of H-Hcy group were higher than those of L-Hcy and M-Hcy group (P=0.0001, P=0.0008). Hcy is an independent predictor for long-term all-cause mortality (odds ratio =2.26, 95% CI=1.23-4.16, P=0.023) and MACE (odds ratio =1.91, 95% CI=1.03-3.51, P=0.039). Receiver operating characteristic curve analysis indicated the predictive cutoff value of Hcy for all-cause mortality was 17.67 μmol/L (0.667, 0.681). In ACS octogenarians, hyperhomocysteinemia is an important predictor for long-term all-cause mortality and MACE.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 12%
Student > Master 3 12%
Unspecified 2 8%
Student > Bachelor 2 8%
Student > Postgraduate 2 8%
Other 3 12%
Unknown 11 42%
Readers by discipline Count As %
Medicine and Dentistry 8 31%
Unspecified 2 8%
Nursing and Health Professions 2 8%
Economics, Econometrics and Finance 1 4%
Psychology 1 4%
Other 1 4%
Unknown 11 42%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2015.
All research outputs
#15,346,908
of 22,828,180 outputs
Outputs from Clinical Interventions in Aging
#1,155
of 1,840 outputs
Outputs of similar age
#209,013
of 353,136 outputs
Outputs of similar age from Clinical Interventions in Aging
#77
of 143 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,840 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,136 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 143 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.