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Improvement of fluvastatin bioavailability by loading on nanostructured lipid carriers

Overview of attention for article published in International Journal of Nanomedicine, September 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

twitter
2 tweeters
googleplus
1 Google+ user

Citations

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39 Dimensions

Readers on

mendeley
46 Mendeley
Title
Improvement of fluvastatin bioavailability by loading on nanostructured lipid carriers
Published in
International Journal of Nanomedicine, September 2015
DOI 10.2147/ijn.s91556
Pubmed ID
Authors

Abdel-Rahim El-Helw, Usama Fahmy

Abstract

The aim of this study is to prepare fluvastatin nanostructured lipid carriers (FLV-NLCs) in order to find an innovative way to alleviate FLV-associated disadvantages. The limitations include poor solubility and extensive first-pass metabolism, resulting in low (30%) bioavailability and short elimination half-life (1-3 hours). FLV-NLCs were prepared by hot emulsification-ultrasonication method. Ten runs were created by three-level factorial design (32) to optimize FLV-NLCs formulation process. In this study, two factors, four responses, and three-level factorial design were endorsed. The studied variables were lipid:oil ratio (X 1) and sonication time (X 2). However, the responses parameter determined the particle size (Y 1, nm), entrapment efficiency percent (EE%, Y 2), particles zeta potential (Y 3), and 80% of the drug release after 24 hours (X 4). Furthermore, stability and in vivo pharmacokinetics were studied in rats. The optimized consisted formula had an average particle size of 165 nm with 75.32% entrapment efficiency and 85.32% of drug released after 24 hours, demonstrating a sustaining drug release over 24 hours. An in vivo pharmacokinetic study revealed enhanced bioavailability by >2.64-fold, and the mean residence time was longer than that of FLV. We concluded that NLCs could be promising carriers for sustained/prolonged FLV release with enhanced oral bioavailability.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Other 11 24%
Researcher 4 9%
Student > Master 4 9%
Student > Ph. D. Student 3 7%
Student > Postgraduate 3 7%
Other 8 17%
Unknown 13 28%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 19 41%
Medicine and Dentistry 3 7%
Agricultural and Biological Sciences 3 7%
Biochemistry, Genetics and Molecular Biology 1 2%
Veterinary Science and Veterinary Medicine 1 2%
Other 1 2%
Unknown 18 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2015.
All research outputs
#2,512,517
of 6,365,090 outputs
Outputs from International Journal of Nanomedicine
#376
of 1,531 outputs
Outputs of similar age
#83,607
of 198,234 outputs
Outputs of similar age from International Journal of Nanomedicine
#41
of 146 outputs
Altmetric has tracked 6,365,090 research outputs across all sources so far. This one has received more attention than most of these and is in the 59th percentile.
So far Altmetric has tracked 1,531 research outputs from this source. They receive a mean Attention Score of 1.8. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,234 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.