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Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice

Overview of attention for article published in International Journal of Nanomedicine, September 2015
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  • Average Attention Score compared to outputs of the same age

Mentioned by

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1 Google+ user

Citations

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12 Dimensions

Readers on

mendeley
16 Mendeley
Title
Hepatotoxicity assessment of Mn-doped ZnS quantum dots after repeated administration in mice
Published in
International Journal of Nanomedicine, September 2015
DOI 10.2147/ijn.s88789
Pubmed ID
Authors

Yanjie Yang, Shuang-Yu Lv, Bianfei Yu, Shuang Xu, Jianmin Shen, Tong Zhao, Haixia Zhang

Abstract

Doped ZnS quantum dots (QDs) have a longer dopant emission lifetime and potentially lower cytotoxicity compared to other doped QDs. The liver is the key organ for clearance and detoxification of xenobiotics by phagocytosis and metabolism. The present study was designed to synthesize and evaluate the hepatotoxicity of Mn-doped ZnS QDs and their polyethylene glycol-coated counterparts (1 mg/kg and 5 mg/kg) in mice. The results demonstrated that daily injection of Mn-doped ZnS QDs and polyethylene glycol-coated QDs via tail vein for 7 days did not influence body weight, relative liver weight, serum aminotransferases (alanine aminotransferase and aspartate aminotransferase), the levels of antioxidant enzymes (catalase, glutathione peroxidase, and superoxide dismutase), or malondialdehyde in the liver. Analysis of hepatocyte ultrastructure showed that Mn-doped ZnS QDs and polyethylene glycol-coated QDs mainly accumulated in mitochondria at 24 hours after repeated intravenous injection. No damage to cell nuclei or mitochondria was observed with either of the QDs. Our results indicate that Mn-doped ZnS QDs did not cause obvious damage to the liver. This study will assist in the development of Mn-doped ZnS QDs-based bioimaging and biomedical applications in the future.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 38%
Researcher 2 13%
Student > Bachelor 2 13%
Professor > Associate Professor 1 6%
Unknown 5 31%
Readers by discipline Count As %
Chemistry 4 25%
Biochemistry, Genetics and Molecular Biology 2 13%
Materials Science 2 13%
Medicine and Dentistry 2 13%
Agricultural and Biological Sciences 1 6%
Other 1 6%
Unknown 4 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2015.
All research outputs
#2,998,713
of 6,360,702 outputs
Outputs from International Journal of Nanomedicine
#875
of 1,530 outputs
Outputs of similar age
#106,983
of 198,186 outputs
Outputs of similar age from International Journal of Nanomedicine
#108
of 146 outputs
Altmetric has tracked 6,360,702 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,530 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,186 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.