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Proteoglycan 4 is a diagnostic biomarker for COPD

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, September 2015
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Mentioned by

twitter
3 tweeters

Citations

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12 Dimensions

Readers on

mendeley
30 Mendeley
Title
Proteoglycan 4 is a diagnostic biomarker for COPD
Published in
International Journal of Chronic Obstructive Pulmonary Disease, September 2015
DOI 10.2147/copd.s90926
Pubmed ID
Authors

Shu-Chuan Ho, Kang-Yun Lee, Hsiao-Chi Chuang, Tzu-Tao Chen, Wen-Te Liu, Chien-Ling Su, Po-Hao Feng, Ling-Ling Chiang, Mauo-Ying Bien

Abstract

The measurement of C-reactive protein (CRP) to confirm the stability of COPD has been reported. However, CRP is a systemic inflammatory biomarker that is related to many other diseases. The objective of this study is to discover a diagnostic biomarker for COPD. Sixty-one subjects with COPD and 15 healthy controls (10 healthy non-smokers and 5 smokers) were recruited for a 1-year follow-up study. Data regarding the 1-year acute exacerbation frequency and changes in lung function were collected. CRP and the identified biomarkers were assessed in the validation COPD cohort patients and healthy subjects. Receiver operating characteristic values of CRP and the identified biomarkers were determined. A validation COPD cohort was used to reexamine the identified biomarker. Correlation of the biomarker with 1-year lung function decline was determined. Proteoglycan 4 (PRG4) was identified as a biomarker in COPD. The serum concentrations of PRG4 in COPD Global initiative for chronic Obstructive Lung Disease (GOLD) stages 1+2 and 3+4 were 10.29 ng/mL and 13.20 ng/mL, respectively; 4.99 ng/mL for healthy controls (P<0.05); and 4.49 ng/mL for healthy smokers (P<0.05). PRG4 was more sensitive and specific than CRP for confirming COPD severity and acute exacerbation frequency. There was no correlation between CRP and PRG4 levels, and PRG4 was negatively correlated with the 1-year change in predicted forced vital capacity percent (R (2)=0.91, P=0.013). PRG4 may be a biomarker for identification of severity in COPD. It was related to the 1-year forced vital capacity decline in COPD patients.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 13%
Researcher 4 13%
Student > Master 4 13%
Student > Ph. D. Student 3 10%
Student > Bachelor 2 7%
Other 5 17%
Unknown 8 27%
Readers by discipline Count As %
Medicine and Dentistry 9 30%
Nursing and Health Professions 3 10%
Biochemistry, Genetics and Molecular Biology 2 7%
Engineering 2 7%
Agricultural and Biological Sciences 2 7%
Other 4 13%
Unknown 8 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2015.
All research outputs
#2,813,092
of 6,386,702 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#368
of 753 outputs
Outputs of similar age
#97,978
of 200,079 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#53
of 86 outputs
Altmetric has tracked 6,386,702 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 753 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,079 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.