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Effect of mild aerobic training on the myocardium of mice with chronic Chagas disease

Overview of attention for article published in Biologics: Targets & Therapy, September 2015
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2 tweeters
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1 Facebook page

Citations

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5 Dimensions

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27 Mendeley
Title
Effect of mild aerobic training on the myocardium of mice with chronic Chagas disease
Published in
Biologics: Targets & Therapy, September 2015
DOI 10.2147/btt.s85283
Pubmed ID
Authors

Fernando Fonseca, Lucila Simardi, Emerson Preto, Abílio Augusto Fragata Filho, Laura beatriz Meisiano Maifrino, Natalia Lima

Abstract

Chronic chagasic heart disease represents extensive remodeling of the cardiovascular system, manifested as cardiac denervation, interstitial mononuclear infiltrate, myocyte and vascular degenerative changes, fibrosis, and hypertrophy. Moreover, aerobic exercises are widely indicated for the treatment of various disorders of the cardiovascular system. To evaluate the right and left ventricles of BALB/c mice with chronic Chagas disease, undergoing mild exercise, by using morphometric and stereological methods. A total of 20 male mice at 4 months of age were used for experiments. The animals were divided into four groups (n=5 in each group): untrained control, trained control, untrained infected (UI), and trained infected (TI). Animals of UI and TI groups were inoculated with 1,000 trypomastigote forms of Trypanosoma cruzi (Y strain), and after 40 days, animals entered chronic phase of the disease. Physical exercise, which included swimming, was performed for 30 minutes daily, five times a week for 8 consecutive weeks at a bath temperature of 30°C. After the trial period, euthanasia and subsequent withdrawal of the heart were done. The organ was prepared by histological staining procedures with hematoxylin-eosin and picrosirius red. We found that the physical training used in our experimental model promoted increase in volume density of capillaries and decrease in volume density of collagen fibers and cross-sectional area of cardiomyocytes in chagasic animals (TI group). By histopathological analysis, we found differences in the inflammatory infiltrate, which was lower in animals of TI group. The training program promoted a recovery of these parameters in the TI group. Our results suggest that low-intensity aerobic exercise acts on morphological and morphometric parameters of the left and right ventricles in mice infected with T. cruzi, reducing the changes caused by the organism and making the results comparable to those of the uninfected control group.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 22%
Student > Master 5 19%
Student > Postgraduate 4 15%
Professor 1 4%
Student > Doctoral Student 1 4%
Other 2 7%
Unknown 8 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 26%
Sports and Recreations 6 22%
Medicine and Dentistry 3 11%
Chemistry 2 7%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 0 0%
Unknown 8 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2015.
All research outputs
#6,047,650
of 10,311,177 outputs
Outputs from Biologics: Targets & Therapy
#85
of 167 outputs
Outputs of similar age
#127,969
of 242,545 outputs
Outputs of similar age from Biologics: Targets & Therapy
#1
of 6 outputs
Altmetric has tracked 10,311,177 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
So far Altmetric has tracked 167 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,545 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them