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Acute coronary syndrome in octogenarians: association between percutaneous coronary intervention and long-term mortality

Overview of attention for article published in Clinical Interventions in Aging, January 2015
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1 tweeter

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55 Mendeley
Title
Acute coronary syndrome in octogenarians: association between percutaneous coronary intervention and long-term mortality
Published in
Clinical Interventions in Aging, January 2015
DOI 10.2147/cia.s89127
Pubmed ID
Authors

Salim Barywani, Per Albertsson, Maria Lindh, Michael Fu, Max Petzold, Shijun Li, Lars Lund, Josefin Ekelund

Abstract

Evidence of improved survival after use of percutaneous coronary intervention (PCI) in elderly patients with acute coronary syndrome (ACS) is limited. We assessed the association between PCI and long-term mortality in octogenarians with ACS. We followed 353 consecutive patients aged ≥80 years hospitalized with ACS during 2006-2007. Among them, 182 were treated with PCI, whereas 171 were not. PCI-treated patients were younger and more often male, and had less stroke and dependency in activities of daily living, but there were no significant differences in occurrence of diabetes mellitus, chronic obstructive pulmonary disease, hypertension, and uncured malignancies between the two groups. The association between PCI and all-cause mortality was assessed in the overall cohort and a 1:1 matched cohort based on propensity score (PS). In overall cohort, 5-year all-cause mortality was 46.2% and 89.5% in the PCI and non-PCI groups, respectively. Cox regression analysis in overall cohort by adjustment for ten baseline variables showed statistically significant association between PCI and reduced long-term mortality (P<0.001, hazard ratio 0.4, 95% confidence interval [CI] 0.2-0.5). In propensity-matched cohort, 5-year all-cause mortality was 54.9% and 83.1% in the PCI and non-PCI groups, respectively. Kaplan-Meier survival curves and log rank test showed significantly improved mean survival rates (P=0.001): 48 months (95% CI 41-54) for PCI-treated patients versus 35 months (95% CI 29-42) for non-PCI-treated patients. Furthermore, by performing Cox regression analysis, PCI was still associated with reduced long-term mortality (P=0.029, hazard ratio 0.5, 95% CI 0.3-0.9) after adjustment for PS and confounders: age, male sex, cognitive deterioration, uncured malignancies, left ventricular ejection fraction ≤45%, estimated glomerular filtration rate ≤35 mL/min, ST-segment elevation myocardial infarction, mitral regurgitation, and medication at discharge with clopidogrel and statins. In octogenarians with ACS, PCI was associated with improved survival from all-cause death over 5 years of follow-up.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Chile 1 2%
Netherlands 1 2%
Unknown 52 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 18%
Researcher 9 16%
Student > Doctoral Student 7 13%
Student > Master 7 13%
Student > Ph. D. Student 4 7%
Other 10 18%
Unknown 8 15%
Readers by discipline Count As %
Medicine and Dentistry 32 58%
Psychology 3 5%
Nursing and Health Professions 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Philosophy 2 4%
Other 4 7%
Unknown 10 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2015.
All research outputs
#18,427,608
of 22,829,083 outputs
Outputs from Clinical Interventions in Aging
#1,441
of 1,840 outputs
Outputs of similar age
#255,875
of 353,131 outputs
Outputs of similar age from Clinical Interventions in Aging
#113
of 143 outputs
Altmetric has tracked 22,829,083 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,840 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,131 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 143 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.