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Independent of DAZL-T54A variant and AZF microdeletion in a sample of Egyptian patients with idiopathic non-obstructed azoospermia

Overview of attention for article published in The application of clinical genetics, July 2018
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Title
Independent of DAZL-T54A variant and AZF microdeletion in a sample of Egyptian patients with idiopathic non-obstructed azoospermia
Published in
The application of clinical genetics, July 2018
DOI 10.2147/tacg.s158297
Pubmed ID
Authors

Mohammed El Shafae, Jehan Sabry, Eman Behiry, Hanan Sabry, Mona Salim, Alaaeldin Fayez

Abstract

The microdeletion events that occur in the Y chromosome-azoospermia factor (AZF) region may lead to dyszoospermia. Also, the deleted azoospermia (DAZ) gene on AZFc and autosomal deleted azoospermia like gene (DAZL) are suggested to represent impairment, so it is interesting to determine the independency pattern of the AZF region and DAZL gene in azoospermic patients. To study the molecular characterization of AZFc and DAZL in 64 idiopathic non-obstructed azoospermia patients and 30 sexually reproductive men. SYBR Green I (Q-PCR) and AZF-STS analysis was used for DAZ gene, and SNV-PCR and confirmative Sanger sequencing for DAZL gene. The present study observed that 15.6% had AZFc microdeletion, out of which 10% had DAZ1/2 deletion, and no T54A variant in the DAZL gene was found. In the current work, the novelty is that spermatogenic impairment phenotype, present with AZFc microdeletions, is independent of the T54A variant in the DAZL gene, and AZFc microdeletions could be a causative agent in spermatogenic impairment.

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Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 27%
Student > Postgraduate 2 18%
Student > Ph. D. Student 2 18%
Professor 1 9%
Lecturer 1 9%
Other 1 9%
Unknown 1 9%
Readers by discipline Count As %
Medicine and Dentistry 4 36%
Agricultural and Biological Sciences 2 18%
Biochemistry, Genetics and Molecular Biology 1 9%
Immunology and Microbiology 1 9%
Unspecified 1 9%
Other 0 0%
Unknown 2 18%